Bioactive Steroids from the Formosan Soft Coral Umbellulifera Petasites

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2016 Oct 12

PMID 27727166

Citations 13

Authors

Chiung-Yao Huang

Che-Wei Chang

Yen-Ju Tseng

Jessica Lee

Ping-Jyun Sung

Jui-Hsin Su

Tsong-Long Hwang

Chang-Feng Dai

Hui-Chun Wang

Jyh-Horng Sheu

Affiliations

Soon will be listed here.

Abstract

Three new steroids, petasitosterones A and B ( and ) and a spirosteroid petasitosterone C (), along with eight known steroids (-), were isolated from a Formosan marine soft coral . The structures of these compounds were elucidated by extensive spectroscopic analysis and comparison of spectroscopic data with those reported. Compound is a marine steroid with a rarely found A/B spiro[4,5]decane ring system. Compounds - and displayed inhibitory activity against the proliferation of a limited panel of cancer cell lines, whereas and exhibited significant anti-inflammatory activity to inhibit nitric oxide (NO) production. The inhibitory activities for superoxide anion generation and elastase release of compounds - were also examined to evaluate the anti-inflammatory potential, and - were shown to exhibit significant activities.

Citing Articles

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