Marine Natural Products with P-glycoprotein Inhibitor Properties

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2014 Jan 24

PMID 24451193

Citations 19

Authors

Dioxelis Lopez

Sergio Martinez-Luis

Affiliations

Soon will be listed here.

Abstract

P-glycoprotein (P-gp) is a protein belonging to the ATP-binding cassette (ABC) transporters superfamily that has clinical relevance due to its role in drug metabolism and multi-drug resistance (MDR) in several human pathogens and diseases. P-gp is a major cause of drug resistance in cancer, parasitic diseases, epilepsy and other disorders. This review article aims to summarize the research findings on the marine natural products with P-glycoprotein inhibitor properties. Natural compounds that modulate P-gp offer great possibilities for semi-synthetic modification to create new drugs and are valuable research tools to understand the function of complex ABC transporters.

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