Stem Cells and the Vasculature

Overview

Journal Nat Med

Specialties General Medicine
Molecular Biology

Date 2011 Nov 9

PMID 22064433

Citations 80

Authors

Victoria L Bautch

Affiliations

Soon will be listed here.

Abstract

Unraveling the contribution of stem and progenitor cells to blood vessel formation and, reciprocally, the importance of blood vessels to the production and function of stem and progenitor cells, has been a major focus of vascular research over the last decade, but has spawned many controversies. Here I review how vascular stem and progenitor cells contribute both vascular and nonvascular cells during development and in disease, and how nonvascular stem and progenitor cells might contribute to vascular lineages. I also discuss the role of the vasculature in forming stem and progenitor cell niches. Finally, I highlight the potential relevance of these relationships to disease etiology and treatment.

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References

Tilki D, Hohn H, Ergun B, Rafii S, Ergun S . Emerging biology of vascular wall progenitor cells in health and disease. Trends Mol Med. 2009; 15(11):501-9. DOI: 10.1016/j.molmed.2009.09.004. View

Hagensen M, Shim J, Thim T, Falk E, Bentzon J . Circulating endothelial progenitor cells do not contribute to plaque endothelium in murine atherosclerosis. Circulation. 2010; 121(7):898-905. DOI: 10.1161/CIRCULATIONAHA.109.885459. View

Psaltis P, Harbuzariu A, Delacroix S, Holroyd E, Simari R . Resident vascular progenitor cells--diverse origins, phenotype, and function. J Cardiovasc Transl Res. 2010; 4(2):161-76. PMC: 3048921. DOI: 10.1007/s12265-010-9248-9. View

Gittenberger-de Groot A, DeRuiter M, Bergwerff M, Poelmann R . Smooth muscle cell origin and its relation to heterogeneity in development and disease. Arterioscler Thromb Vasc Biol. 1999; 19(7):1589-94. DOI: 10.1161/01.atv.19.7.1589. View

Kokovay E, Goderie S, Wang Y, Lotz S, Lin G, Sun Y . Adult SVZ lineage cells home to and leave the vascular niche via differential responses to SDF1/CXCR4 signaling. Cell Stem Cell. 2010; 7(2):163-73. PMC: 2916873. DOI: 10.1016/j.stem.2010.05.019. View

Boscolo E, Stewart C, Greenberger S, Wu J, Durham J, Herman I . JAGGED1 signaling regulates hemangioma stem cell-to-pericyte/vascular smooth muscle cell differentiation. Arterioscler Thromb Vasc Biol. 2011; 31(10):2181-92. PMC: 3174332. DOI: 10.1161/ATVBAHA.111.232934. View

Boye E, Yu Y, Paranya G, Mulliken J, Olsen B, Bischoff J . Clonality and altered behavior of endothelial cells from hemangiomas. J Clin Invest. 2001; 107(6):745-52. PMC: 208946. DOI: 10.1172/JCI11432. View

Moore K, Lemischka I . Stem cells and their niches. Science. 2006; 311(5769):1880-5. DOI: 10.1126/science.1110542. View

Kissa K, Herbomel P . Blood stem cells emerge from aortic endothelium by a novel type of cell transition. Nature. 2010; 464(7285):112-5. DOI: 10.1038/nature08761. View

10.

Purhonen S, Palm J, Rossi D, Kaskenpaa N, Rajantie I, Yla-Herttuala S . Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc Natl Acad Sci U S A. 2008; 105(18):6620-5. PMC: 2365563. DOI: 10.1073/pnas.0710516105. View

11.

Zeisberg E, Potenta S, Xie L, Zeisberg M, Kalluri R . Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res. 2007; 67(21):10123-8. DOI: 10.1158/0008-5472.CAN-07-3127. View

12.

Campagnolo P, Cesselli D, Al Haj Zen A, Beltrami A, Krankel N, Katare R . Human adult vena saphena contains perivascular progenitor cells endowed with clonogenic and proangiogenic potential. Circulation. 2010; 121(15):1735-45. PMC: 2917746. DOI: 10.1161/CIRCULATIONAHA.109.899252. View

13.

Walter J, North P, Waner M, Mizeracki A, Blei F, Walker J . Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma. Genes Chromosomes Cancer. 2002; 33(3):295-303. DOI: 10.1002/gcc.10028. View

14.

Bu L, Jiang X, Martin-Puig S, Caron L, Zhu S, Shao Y . Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature. 2009; 460(7251):113-7. DOI: 10.1038/nature08191. View

15.

Medici D, Shore E, Lounev V, Kaplan F, Kalluri R, Olsen B . Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med. 2010; 16(12):1400-6. PMC: 3209716. DOI: 10.1038/nm.2252. View

16.

Majesky M, Dong X, Regan J, Hoglund V . Vascular smooth muscle progenitor cells: building and repairing blood vessels. Circ Res. 2011; 108(3):365-77. PMC: 3382110. DOI: 10.1161/CIRCRESAHA.110.223800. View

17.

Pardanaud L, Luton D, Prigent M, Bourcheix L, Catala M, Dieterlen-Lievre F . Two distinct endothelial lineages in ontogeny, one of them related to hemopoiesis. Development. 1996; 122(5):1363-71. DOI: 10.1242/dev.122.5.1363. View

18.

Ambler C, Nowicki J, Burke A, Bautch V . Assembly of trunk and limb blood vessels involves extensive migration and vasculogenesis of somite-derived angioblasts. Dev Biol. 2001; 234(2):352-64. DOI: 10.1006/dbio.2001.0267. View

19.

Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T . Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997; 275(5302):964-7. DOI: 10.1126/science.275.5302.964. View

20.

Jinnin M, Medici D, Park L, Limaye N, Liu Y, Boscolo E . Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. Nat Med. 2008; 14(11):1236-46. PMC: 2593632. DOI: 10.1038/nm.1877. View