The Planar Cell Polarity Pathway in Vertebrate Epidermal Development, Homeostasis and Repair

Overview

Journal Organogenesis

Specialties Anatomy & Histology
Biology
Biotechnology

Date 2011 Nov 2

PMID 22041517

Citations 19

Authors

Sebastian Dworkin

Stephen M Jane

Charbel Darido

Affiliations

Soon will be listed here.

Abstract

The planar cell polarity (PCP) pathway plays a critical role in diverse developmental processes that require coordinated cellular movement, including neural tube closure and renal tubulogenesis. Recent studies have demonstrated that this pathway also has emerging relevance to the epidermis, as PCP signaling underpins many aspects of skin biology and pathology, including epidermal development, hair orientation, stem cell division and cancer. Coordinated cellular movement required for epidermal repair in mammals is also regulated by PCP signaling, and in this context, a new PCP gene encoding the developmental transcription factor Grainyhead-like 3 (Grhl3) is critical. This review focuses on the role that PCP signaling plays in the skin across a variety of epidermal functions and highlights perturbations that induce epidermal pathologies.

Citing Articles

Planar Cell Polarity Signaling: Coordinated Crosstalk for Cell Orientation.

Kacker S, Parsad V, Singh N, Hordiichuk D, Alvarez S, Gohar M J Dev Biol. 2024; 12(2).

PMID: 38804432 PMC: 11130840. DOI: 10.3390/jdb12020012.

Grainyhead-like (Grhl) Target Genes in Development and Cancer.

Gasperoni J, Fuller J, Darido C, Wilanowski T, Dworkin S Int J Mol Sci. 2022; 23(5).

PMID: 35269877 PMC: 8911041. DOI: 10.3390/ijms23052735.

The Balance between Differentiation and Terminal Differentiation Maintains Oral Epithelial Homeostasis.

Bai Y, Boath J, White G, Kariyawasam U, Farah C, Darido C Cancers (Basel). 2021; 13(20).

PMID: 34680271 PMC: 8534139. DOI: 10.3390/cancers13205123.

Meta-Analysis of Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways.

Mathiyalagan N, Miles L, Anderson P, Wilanowski T, Grills B, McDonald S Genes (Basel). 2019; 10(11).

PMID: 31683705 PMC: 6896185. DOI: 10.3390/genes10110876.

Targeted Therapy Against the Cell of Origin in Cutaneous Squamous Cell Carcinoma.

Goldie S, Chincarini G, Darido C Int J Mol Sci. 2019; 20(9).

PMID: 31060263 PMC: 6539622. DOI: 10.3390/ijms20092201.

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