Sebastian Dworkin
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Explore the profile of Sebastian Dworkin including associated specialties, affiliations and a list of published articles.
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53
Citations
1288
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Recent Articles
1.
Mathiyalagan N, Johnson T, Di Pastena Z, Fuller J, Miles L, Dworkin S
Dev Dyn
. 2025 Feb;
PMID: 39976312
Background: Environmental influence is critical for embryogenesis but is significantly under-appreciated under lab conditions, which are not typically designed to robustly test environmental variability. Here, we report environmental effects on...
2.
Mele S, Martelli F, Barlow C, Jefferies G, Dworkin S, Christodoulou J, et al.
J Inherit Metab Dis
. 2024 Dec;
48(1):e12840.
PMID: 39727068
Short-chain enoyl-CoA hydratase 1 deficiency (ECHS1D) is a rare genetic disorder caused by biallelic pathogenic variants in the ECHS1 gene. ECHS1D is characterised by severe neurological and physical impairment that...
3.
Dinevska M, McAloney L, Widodo S, Filiz G, Anderson J, Dworkin S, et al.
Carcinogenesis
. 2024 Dec;
46(1).
PMID: 39672957
Testicular tumors are the most common malignancy of young men, and tumors affecting the testis are caused by somatic mutations in germ or germ-like cells. The PI3K pathway is constitutively...
4.
Taracha-Wisniewska A, Parks E, Miller M, Lipinska-Zubrycka L, Dworkin S, Wilanowski T
Int J Mol Sci
. 2024 Jul;
25(14).
PMID: 39063155
Vitamin D plays an important pleiotropic role in maintaining global homeostasis of the human body. Its functions go far beyond skeletal health, playing a crucial role in a plethora of...
5.
Green S, Silvester E, Dworkin S, Shakya M, Klein A, Lowe R, et al.
Aquat Toxicol
. 2024 May;
272:106963.
PMID: 38776608
Contaminants are increasingly accumulating in aquatic environments and biota, with potential adverse effects on individual organisms, communities and ecosystems. However, studies that explore the molecular changes in fish caused by...
6.
de Vries M, Carpinelli M, Fuller J, Sutton Y, Partridge D, Auden A, et al.
Development
. 2024 Feb;
151(5).
PMID: 38300806
Defective tissue fusion during mammalian embryogenesis results in congenital anomalies, such as exencephaly, spina bifida and cleft lip and/or palate. The highly conserved transcription factor grainyhead-like 2 (Grhl2) is a...
7.
Gasperoni J, Tran S, Grommen S, De Groef B, Dworkin S
Mol Neurobiol
. 2024 Jan;
61(8):5851-5867.
PMID: 38240991
The pleomorphic adenoma gene 1 (Plag1) is a transcription factor involved in the regulation of growth and cellular proliferation. Here, we report the spatial distribution and functional implications of PLAG1...
8.
9.
Gasperoni J, Dworkin S
Methods Mol Biol
. 2023 Dec;
2746:155-163.
PMID: 38070088
Cryopreservation and immunohistochemistry offer a comprehensive, robust, and simple methodology to investigate neural patterning and cellular function. Rapid freezing of the whole brain allows excellent preservation of neural ultrastructure and...
10.
Gasperoni J, Dworkin S
Methods Mol Biol
. 2023 Dec;
2746:109-120.
PMID: 38070084
Neural stem-progenitor cells (NSPCs) are multipotent, self-renewing cells that generate radial glial cells (RGC). RGCs then give rise to neurons and glia during neural development. Here, we describe the process...