Direct Demonstration of the Lectin Activity of Gp90MEL, a Lymphocyte Homing Receptor

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 1990 Sep 1

PMID 2202735

Citations 34

Authors

Y Imai

D D True

M S Singer

S D Rosen

Affiliations

Soon will be listed here.

Abstract

Considerable evidence implicates gp90MEL as a lymphocyte homing receptor mediating lymphocyte attachment to high endothelial venules of lymph nodes in mouse. The protein appears to function as a calcium-dependent, lectin-like receptor as inferred primarily by the ability of specific carbohydrates to block its function and by the presence of a calcium-type lectin domain in its primary sequence. An ELISA assay is described which provides the first demonstration that the isolated protein has lectin activity and allows a further definition of its carbohydrate specificity. In addition to the monosaccharides mannose-6-phosphate and fructose-1-phosphate, ligand activity is shown for the sulfated glycolipid, sulfatide, and for two sulfated fucose-containing polysaccharides (fucoidin and egg jelly coat) from nonmammalian sources.

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