Possible Role for Cell-surface Carbohydrate-binding Molecules in Lymphocyte Recirculation

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 1983 Mar 1

PMID 6833380

Citations 50

Authors

L M Stoolman

S D Rosen

Affiliations

Soon will be listed here.

Abstract

We are investigating the hypothesis that carbohydrate-binding molecules on the cell surface are involved in the recirculation of lymphocytes from the bloodstream into lymphoid organs. This phenomenon requires the specific attachment of circulating lymphocytes to the endothelial cells of postcapillary venules. Using an in vitro assay to measure the adhesive interaction between lymphocytes and postcapillary venules, we have found that L-fucose, D mannose, and the L-fucose-rich, sulfated polysaccharide fucoidin specifically inhibit this binding interaction. L-fucose shows stereo-selective inhibitory activity at concentrations greater than 18 mM while fucoidin produces 50% inhibition at approximately 1-5 X 10(-8) M. Fucoidin appears to interact with the lymphocyte, and not the postcapillary venule, to inhibit binding. These data suggest that cell surface carbohydrates (fucoselike) and carbohydrate-binding molecules (cell surface lectins) may contribute to the specific attachment of lymphocytes to postcapillary venules.

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References

Cox R, GESNER B . Effect of simple sugars on the morphology and growth pattern of mammalian cell cultures. Proc Natl Acad Sci U S A. 1965; 54(6):1571-9. PMC: 300516. DOI: 10.1073/pnas.54.6.1571. View

Borberg H, Yesner I, Gesner B, Silber R . The effect of N acetyl C-galactosamine and other sugars on the mitogenic activity and attachment of PHA to tonsil cells. Blood. 1968; 31(6):747-57. View

Ford W, Gowans J . The traffic of lymphocytes. Semin Hematol. 1969; 6(1):67-83. View

WAYMOUTH C . Osmolality of mammalian blood and of media for culture of mammalian cells. In Vitro. 1970; 6(2):109-27. DOI: 10.1007/BF02616113. View

Rosen S, Kafka J, Simpson D, Barondes S . Developmentally regulated, carbohydrate-binding protein in Dictyostelium discoideum. Proc Natl Acad Sci U S A. 1973; 70(9):2554-7. PMC: 427054. DOI: 10.1073/pnas.70.9.2554. View

Ford W . Lymphocyte migration and immune responses. Prog Allergy. 1975; 19:1-59. DOI: 10.1159/000313381. View

Stamper Jr H, Woodruff J . Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules. J Exp Med. 1976; 144(3):828-33. PMC: 2190398. DOI: 10.1084/jem.144.3.828. View

Krantz M, Holtzman N, Stowell C, Lee Y . Attachment of thioglycosides to proteins: enhancement of liver membrane binding. Biochemistry. 1976; 15(18):3963-8. DOI: 10.1021/bi00663a009. View

Anderson A, Anderson N . Lymphocyte emigration from high endothelial venules in rat lymph nodes. Immunology. 1976; 31(5):731-48. PMC: 1445135. View

10.

Stamper Jr H, Woodruff J . An in vitro model of lymphocyte homing. I. Characterization of the interaction between thoracic duct lymphocytes and specialized high-endothelial venules of lymph nodes. J Immunol. 1977; 119(2):772-80. View

11.

Goldstein I, Hayes C . The lectins: carbohydrate-binding proteins of plants and animals. Adv Carbohydr Chem Biochem. 1978; 35:127-340. DOI: 10.1016/s0065-2318(08)60220-6. View

12.

DULANEY J . Binding interactions of glycoproteins with lectins. Mol Cell Biochem. 1978; 21(1):43-63. DOI: 10.1007/BF00230195. View

13.

Paulson J, Sadler J, Hill R . Restoration of specific myxovirus receptors to asialoerythrocytes by incorporation of sialic acid with pure sialyltransferases. J Biol Chem. 1979; 254(6):2120-4. View

14.

Ray J, Shinnick T, Lerner R . A mutation altering the function of a carbohydrate binding protein blocks cell-cell cohesion in developing Dictyostelium discoideum. Nature. 1979; 279(5710):215-21. DOI: 10.1038/279215a0. View

15.

Butcher E, Scollay R, Weissman I . Evidence of continuous evolutionary change in structures mediating adherence of lymphocytes to specialised venules. Nature. 1979; 280(5722):496-8. DOI: 10.1038/280496a0. View

16.

FRAZIER W, Glaser L . Surface components and cell recognition. Annu Rev Biochem. 1979; 48:491-523. DOI: 10.1146/annurev.bi.48.070179.002423. View

17.

Grabel L, Rosen S, Martin G . Teratocarcinoma stem cells have a cell surface carbohydrate-binding component implicated in cell-cell adhesion. Cell. 1979; 17(3):477-84. DOI: 10.1016/0092-8674(79)90255-1. View

18.

Butcher E, Scollay R, Weissman I . Lymphocyte adherence to high endothelial venules: characterization of a modified in vitro assay, and examination of the binding of syngeneic and allogeneic lymphocyte populations. J Immunol. 1979; 123(5):1996-2003. View

19.

Ofek I, Beachey E . Bacterial adherence. Adv Intern Med. 1980; 25:503-32. View

20.

Barondes S . Lectins: their multiple endogenous cellular functions. Annu Rev Biochem. 1981; 50:207-31. DOI: 10.1146/annurev.bi.50.070181.001231. View