Electrode Position and the Clinical Outcome After Bilateral Subthalamic Nucleus Stimulation

Overview

Journal J Korean Med Sci

Specialty General Medicine

Date 2011 Oct 25

PMID 22022189

Citations 9

Authors

Sun Ha Paek

Jee-Young Lee

Han-Joon Kim

Daehee Kang

Yong Hoon Lim

Mi Ryoung Kim

Cheolyoung Kim

Beom Seok Jeon

Dong Gyu Kim

Affiliations

Soon will be listed here.

Abstract

We compared the surgical outcome with electrode positions after bilateral subthalamic nucleus (STN) stimulation surgery for Parkinson's disease. Fifty-seven patients treated with bilateral STN stimulations were included in this study. Electrode positions were determined in the fused images of preoperative MRI and postoperative CT taken at six months after surgery. The patients were divided into three groups: group I, both electrodes in the STN; group II, only one electrode in the STN; group III, neither electrode in the STN. Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn and Yahr stage, and activities of daily living scores significantly improved at 6 and 12 months after STN stimulation in both group I and II. The off-time UPDRS III speech subscore significantly improved (1.6 ± 0.7 at baseline vs 1.3 ± 0.8 at 6 and 12 months, P < 0.01) with least L-dopa equivalent daily dose (LEDD) (844.6 ± 364.1 mg/day at baseline; 279.4 ± 274.6 mg/day at 6 months; and 276.0 ± 301.6 mg/day at 12 months, P < 0.001) at 6 and 12 months after STN deep brain stimulation (DBS) in the group I. Our findings suggest that the better symptom relief including speech with a reduced LEDD is expected in the patients whose electrodes are accurately positioned in both STN.

Citing Articles

Motor outcome and electrode location in deep brain stimulation in Parkinson's disease.

Koivu M, Huotarinen A, Scheperjans F, Laakso A, Kivisaari R, Pekkonen E Brain Behav. 2018; 8(7):e01003.

PMID: 29851316 PMC: 6043715. DOI: 10.1002/brb3.1003.

Visualizing the Human Subcortex Using Ultra-high Field Magnetic Resonance Imaging.

Keuken M, Isaacs B, Trampel R, van der Zwaag W, Forstmann B Brain Topogr. 2018; 31(4):513-545.

PMID: 29497874 PMC: 5999196. DOI: 10.1007/s10548-018-0638-7.

Coordinated reset stimulation in a large-scale model of the STN-GPe circuit.

Ebert M, Hauptmann C, Tass P Front Comput Neurosci. 2014; 8:154.

PMID: 25505882 PMC: 4245901. DOI: 10.3389/fncom.2014.00154.

[Deep brain stimulation using simultaneous stereotactic electrode placement: an alternative to conventional functional stereotaxy?].

Matzke C, Hammer N, Weise D, Lindner D, Fritzsch D, Classen J Nervenarzt. 2014; 85(12):1561-8.

PMID: 25431126 DOI: 10.1007/s00115-014-4214-4.

Predictive factors of speech intelligibility following subthalamic nucleus stimulation in consecutive patients with Parkinson's disease.

Tripoliti E, Limousin P, Foltynie T, Candelario J, Aviles-Olmos I, Hariz M Mov Disord. 2014; 29(4):532-8.

PMID: 24532491 PMC: 8759591. DOI: 10.1002/mds.25816.

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