Iodide-catalyzed Reductions: Development of a Synthesis of Phenylacetic Acids

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2011 Oct 13

PMID 21988471

Citations 12

Authors

Jacqueline E Milne

Thomas Storz

John T Colyer

Oliver R Thiel

Mina Dilmeghani Seran

Robert D Larsen

Jerry A Murry

Affiliations

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Abstract

A new convenient and scalable synthesis of phenylacetic acids has been developed via the iodide catalyzed reduction of mandelic acids. The procedure relies on in situ generation of hydroiodic acid from catalytic sodium iodide, employing phosphorus acid as the stoichiometric reductant.

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