Introduction to Induced Pluripotent Stem Cells: Advancing the Potential for Personalized Medicine

Overview

Journal World Neurosurg

Publisher Elsevier

Date 2011 Oct 12

PMID 21986423

Citations 18

Authors

Johnathan D Ebben

Michael Zorniak

Paul A Clark

John S Kuo

Affiliations

Soon will be listed here.

Abstract

Induced pluripotent stem (iPS) cell technology has enormous potential to advance medical therapy by personalizing regenerative medicine and creating novel human disease models for research and therapeutic testing. Before this technology is broadly used in the clinic, we must realistically evaluate its disease modeling and therapeutic potential. Recent advances including the use of iPS cells to successfully model spinal muscular atrophy in vitro, as well as new techniques in generating iPS cells with recombinant proteins have accelerated the prospects of iPS cells for clinical use in regenerative therapy. This review explores the development and limitations of iPS cell technology, presents a critical comparison of iPS cells and embryonic stem cells, and discusses potential clinical applications and future research directions.

Citing Articles

In Vitro Models of the Human Blood-Brain Barrier Utilising Human Induced Pluripotent Stem Cells: Opportunities and Challenges.

Pervaiz I, Al-Ahmad A Methods Mol Biol. 2022; 2492:53-72.

PMID: 35733038 DOI: 10.1007/978-1-0716-2289-6_3.

Feasibility and application of polygenic score analysis to the morphology of human-induced pluripotent stem cells.

Coleman J Mol Genet Genomics. 2022; 297(4):1111-1122.

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Use of buccal fat pad-derived stem cells cultured on bioceramics for repair of critical-sized mandibular defects in healthy and osteoporotic rats.

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Therapeutic Potential of Vital Transcription Factors in Alzheimer's and Parkinson's Disease With Particular Emphasis on Transcription Factor EB Mediated Autophagy.

Rai S, Tiwari N, Singh P, Mishra D, Singh A, Hooshmandi E Front Neurosci. 2021; 15:777347.

PMID: 34970114 PMC: 8712758. DOI: 10.3389/fnins.2021.777347.

Analysis of the stability of 70 housekeeping genes during iPS reprogramming.

Panina Y, Germond A, Watanabe T Sci Rep. 2020; 10(1):21711.

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