Bone and the Perimenopause

Overview

Journal Obstet Gynecol Clin North Am

Specialty Gynecology & Obstetrics

Date 2011 Oct 4

PMID 21961717

Citations 18

Authors

Joan C Lo

Sherri-Ann M Burnett-Bowie

Joel S Finkelstein

Affiliations

Soon will be listed here.

Abstract

Loss of ovarian function has a profound impact on female skeletal health. Bone mineral density findings from the Study of Women's Health Across the Nation demonstrate an accelerated rate of bone loss during the menopausal transition. The greatest reduction occurs in the year before the final menstrual period and the first 2 years thereafter. Clinical management includes maintenance of adequate dietary calcium and vitamin D intake, attention to modifiable risk factors, and osteoporosis screening. Indications, benefits, and risks of pharmacologic osteoporosis therapy should be assessed individually; there are currently no established guidelines addressing the treatment and prevention of osteoporosis in perimenopausal women.

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References

Wortsman J, Matsuoka L, Chen T, Lu Z, Holick M . Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000; 72(3):690-3. DOI: 10.1093/ajcn/72.3.690. View

Sowers M, Zheng H, Jannausch M, McConnell D, Nan B, Harlow S . Amount of bone loss in relation to time around the final menstrual period and follicle-stimulating hormone staging of the transmenopause. J Clin Endocrinol Metab. 2010; 95(5):2155-62. PMC: 2869543. DOI: 10.1210/jc.2009-0659. View

Bauer D, Sklarin P, Stone K, Black D, Nevitt M, Ensrud K . Biochemical markers of bone turnover and prediction of hip bone loss in older women: the study of osteoporotic fractures. J Bone Miner Res. 1999; 14(8):1404-10. DOI: 10.1359/jbmr.1999.14.8.1404. View

Holmberg A, Johnell O, Nilsson P, Nilsson J, Berglund G, Akesson K . Risk factors for fragility fracture in middle age. A prospective population-based study of 33,000 men and women. Osteoporos Int. 2006; 17(7):1065-77. DOI: 10.1007/s00198-006-0137-7. View

Reid I, Mason B, Horne A, Ames R, Reid H, Bava U . Randomized controlled trial of calcium in healthy older women. Am J Med. 2006; 119(9):777-85. DOI: 10.1016/j.amjmed.2006.02.038. View

Nordin B, Wishart J, Clifton P, McArthur R, Scopacasa F, Need A . A longitudinal study of bone-related biochemical changes at the menopause. Clin Endocrinol (Oxf). 2004; 61(1):123-30. DOI: 10.1111/j.1365-2265.2004.02066.x. View

Delmas P, Eastell R, Garnero P, Seibel M, Stepan J . The use of biochemical markers of bone turnover in osteoporosis. Committee of Scientific Advisors of the International Osteoporosis Foundation. Osteoporos Int. 2001; 11 Suppl 6:S2-17. DOI: 10.1007/s001980070002. View

Bischoff-Ferrari H, Willett W, Wong J, Giovannucci E, Dietrich T, Dawson-Hughes B . Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA. 2005; 293(18):2257-64. DOI: 10.1001/jama.293.18.2257. View

Baim S, Binkley N, Bilezikian J, Kendler D, Hans D, Lewiecki E . Official Positions of the International Society for Clinical Densitometry and executive summary of the 2007 ISCD Position Development Conference. J Clin Densitom. 2008; 11(1):75-91. DOI: 10.1016/j.jocd.2007.12.007. View

10.

Cauley J, Seeley D, Ensrud K, Ettinger B, Black D, Cummings S . Estrogen replacement therapy and fractures in older women. Study of Osteoporotic Fractures Research Group. Ann Intern Med. 1995; 122(1):9-16. DOI: 10.7326/0003-4819-122-1-199501010-00002. View

11.

Abel M, Huhtaniemi I, Pakarinen P, Kumar T, Charlton H . Age-related uterine and ovarian hypertrophy in FSH receptor knockout and FSHbeta subunit knockout mice. Reproduction. 2003; 125(2):165-73. DOI: 10.1530/rep.0.1250165. View

12.

Finkelstein J, Brockwell S, Mehta V, Greendale G, Sowers M, Ettinger B . Bone mineral density changes during the menopause transition in a multiethnic cohort of women. J Clin Endocrinol Metab. 2007; 93(3):861-8. PMC: 2266953. DOI: 10.1210/jc.2007-1876. View

13.

Reeve J, Walton J, Russell L, Lunt M, Wolman R, Abraham R . Determinants of the first decade of bone loss after menopause at spine, hip and radius. QJM. 2000; 92(5):261-73. DOI: 10.1093/qjmed/92.5.261. View

14.

Riis B, Hansen M, Jensen A, Overgaard K, Christiansen C . Low bone mass and fast rate of bone loss at menopause: equal risk factors for future fracture: a 15-year follow-up study. Bone. 1996; 19(1):9-12. DOI: 10.1016/8756-3282(96)00102-0. View

15.

Iqbal J, Sun L, Kumar T, Blair H, Zaidi M . Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formation. Proc Natl Acad Sci U S A. 2006; 103(40):14925-30. PMC: 1595452. DOI: 10.1073/pnas.0606805103. View

16.

Tremollieres F, Cochet T, Cohade C, Pouilles J, Ribot C . Fracture risk in early postmenopausal women assessed using FRAX. Joint Bone Spine. 2010; 77(4):345-8. DOI: 10.1016/j.jbspin.2010.04.012. View

17.

Ensrud K, Ewing S, Stone K, Cauley J, Bowman P, Cummings S . Intentional and unintentional weight loss increase bone loss and hip fracture risk in older women. J Am Geriatr Soc. 2003; 51(12):1740-7. DOI: 10.1046/j.1532-5415.2003.51558.x. View

18.

Rosen C, Chesnut 3rd C, Mallinak N . The predictive value of biochemical markers of bone turnover for bone mineral density in early postmenopausal women treated with hormone replacement or calcium supplementation. J Clin Endocrinol Metab. 1997; 82(6):1904-10. DOI: 10.1210/jcem.82.6.4004. View

19.

Ahlborg H, Johnell O, Turner C, Rannevik G, Karlsson M . Bone loss and bone size after menopause. N Engl J Med. 2003; 349(4):327-34. DOI: 10.1056/NEJMoa022464. View

20.

Hansen M, Overgaard K, Riis B, Christiansen C . Role of peak bone mass and bone loss in postmenopausal osteoporosis: 12 year study. BMJ. 1991; 303(6808):961-4. PMC: 1671323. DOI: 10.1136/bmj.303.6808.961. View