Nutrition and Bone Marrow Adiposity in Relation to Bone Health

Overview

Journal Physiol Res

Specialty Physiology

Date 2024 May 16

PMID 38752771

Authors

M Dzubanova

A Benova

M Ferencakova

R Coupeau

M Tencerova

Affiliations

Soon will be listed here.

Abstract

Bone remodeling is energetically demanding process. Energy coming from nutrients present in the diet contributes to function of different cell type including osteoblasts, osteocytes and osteoclasts in bone marrow participating in bone homeostasis. With aging, obesity and osteoporosis the function of key building blocks, bone marrow stromal cells (BMSCs), changes towards higher accumulation of bone marrow adipose tissue (BMAT) and decreased bone mass, which is affected by diet and sex dimorphism. Men and women have unique nutritional needs based on physiological and hormonal changes across the life span. However, the exact molecular mechanisms behind these pathophysiological conditions in bone are not well-known. In this review, we focus on bone and BMAT physiology in men and women and how this approach has been taken by animal studies. Furthermore, we discuss the different diet interventions and impact on bone and BMAT in respect to sex differences. We also discuss the future perspective on precision nutrition with a consideration of sex-based differences which could bring better understanding of the diet intervention in bone health and weight management.

Citing Articles

Impact of Vitamin D Status and Nutrition on the Occurrence of Long Bone Fractures Due to Falls in Elderly Subjects in the Vojvodina Region of Serbia.

Gvozdenovic N, Sarac I, Coric A, Karan S, Nikolic S, Zdrale I Nutrients. 2024; 16(16).

PMID: 39203838 PMC: 11356805. DOI: 10.3390/nu16162702.

References

Kruger M, Coetzee M, Haag M, Weiler H . Long-chain polyunsaturated fatty acids: selected mechanisms of action on bone. Prog Lipid Res. 2010; 49(4):438-49. DOI: 10.1016/j.plipres.2010.06.002. View

Baek K, Bloomfield S . Blocking β-adrenergic signaling attenuates reductions in circulating leptin, cancellous bone mass, and marrow adiposity seen with dietary energy restriction. J Appl Physiol (1985). 2012; 113(11):1792-801. DOI: 10.1152/japplphysiol.00187.2012. View

Plummer J, Park M, Perodin F, Horowitz M, Hens J . Methionine-Restricted Diet Increases miRNAs That Can Target RUNX2 Expression and Alters Bone Structure in Young Mice. J Cell Biochem. 2016; 118(1):31-42. PMC: 5426510. DOI: 10.1002/jcb.25604. View

Kricun M . Red-yellow marrow conversion: its effect on the location of some solitary bone lesions. Skeletal Radiol. 1985; 14(1):10-9. DOI: 10.1007/BF00361188. View

Michalowska M, Znorko B, Kaminski T, Oksztulska-Kolanek E, Pawlak D . New insights into tryptophan and its metabolites in the regulation of bone metabolism. J Physiol Pharmacol. 2016; 66(6):779-91. View

Kugel H, Jung C, Schulte O, Heindel W . Age- and sex-specific differences in the 1H-spectrum of vertebral bone marrow. J Magn Reson Imaging. 2001; 13(2):263-8. DOI: 10.1002/1522-2586(200102)13:2<263::aid-jmri1038>3.0.co;2-m. View

Nieuwoudt M, Shahlori R, Naot D, Patel R, Holtkamp H, Aguergaray C . Raman spectroscopy reveals age- and sex-related differences in cortical bone from people with osteoarthritis. Sci Rep. 2020; 10(1):19443. PMC: 7656243. DOI: 10.1038/s41598-020-76337-2. View

Beekman K, Duque G, Corsi A, Tencerova M, Bisschop P, Paccou J . Osteoporosis and Bone Marrow Adipose Tissue. Curr Osteoporos Rep. 2022; 21(1):45-55. DOI: 10.1007/s11914-022-00768-1. View

Nakada D, Oguro H, Levi B, Ryan N, Kitano A, Saitoh Y . Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy. Nature. 2014; 505(7484):555-8. PMC: 4015622. DOI: 10.1038/nature12932. View

10.

Cruzat V, Rogero M, Tirapegui J . Effects of supplementation with free glutamine and the dipeptide alanyl-glutamine on parameters of muscle damage and inflammation in rats submitted to prolonged exercise. Cell Biochem Funct. 2009; 28(1):24-30. DOI: 10.1002/cbf.1611. View

11.

Baum T, Rohrmeier A, Syvari J, Diefenbach M, Franz D, Dieckmeyer M . Anatomical Variation of Age-Related Changes in Vertebral Bone Marrow Composition Using Chemical Shift Encoding-Based Water-Fat Magnetic Resonance Imaging. Front Endocrinol (Lausanne). 2018; 9:141. PMC: 5893948. DOI: 10.3389/fendo.2018.00141. View

12.

Cunha M, da Silva Lima F, Vinolo M, Hastreiter A, Curi R, Borelli P . Protein malnutrition induces bone marrow mesenchymal stem cells commitment to adipogenic differentiation leading to hematopoietic failure. PLoS One. 2013; 8(3):e58872. PMC: 3597562. DOI: 10.1371/journal.pone.0058872. View

13.

Palacios-Gonzalez B, Ramirez-Salazar E, Rivera-Paredez B, Quiterio M, Flores Y, Macias-Kauffer L . A Multi-Omic Analysis for Low Bone Mineral Density in Postmenopausal Women Suggests a RELATIONSHIP between Diet, Metabolites, and Microbiota. Microorganisms. 2020; 8(11). PMC: 7690388. DOI: 10.3390/microorganisms8111630. View

14.

Limonard E, Veldhuis-Vlug A, van Dussen L, Runge J, Tanck M, Endert E . Short-Term Effect of Estrogen on Human Bone Marrow Fat. J Bone Miner Res. 2015; 30(11):2058-66. DOI: 10.1002/jbmr.2557. View

15.

Hogstrom M, Nordstrom P, Nordstrom A . n-3 Fatty acids are positively associated with peak bone mineral density and bone accrual in healthy men: the NO2 Study. Am J Clin Nutr. 2007; 85(3):803-7. DOI: 10.1093/ajcn/85.3.803. View

16.

Dunsworth H . Expanding the evolutionary explanations for sex differences in the human skeleton. Evol Anthropol. 2020; 29(3):108-116. DOI: 10.1002/evan.21834. View

17.

Sartori T, Santos A, da Silva R, Kodja G, Rogero M, Borelli P . Branched chain amino acids improve mesenchymal stem cell proliferation, reducing nuclear factor kappa B expression and modulating some inflammatory properties. Nutrition. 2020; 78:110935. DOI: 10.1016/j.nut.2020.110935. View

18.

Dong K, Hao P, Xu S, Liu S, Zhou W, Yue X . Alpha-Lipoic Acid Alleviates High-Glucose Suppressed Osteogenic Differentiation of MC3T3-E1 Cells via Antioxidant Effect and PI3K/Akt Signaling Pathway. Cell Physiol Biochem. 2017; 42(5):1897-1906. DOI: 10.1159/000479605. View

19.

Karastergiou K, Smith S, Greenberg A, Fried S . Sex differences in human adipose tissues - the biology of pear shape. Biol Sex Differ. 2012; 3(1):13. PMC: 3411490. DOI: 10.1186/2042-6410-3-13. View

20.

Li Z, Hardij J, Bagchi D, Scheller E, MacDougald O . Development, regulation, metabolism and function of bone marrow adipose tissues. Bone. 2018; 110:134-140. PMC: 6277028. DOI: 10.1016/j.bone.2018.01.008. View