Role of Osteoclasts and Interleukin-17 in the Pathogenesis of Rheumatoid Arthritis: Crucial 'human Osteoclastology'

Overview

Journal J Bone Miner Metab

Specialty Endocrinology

Date 2011 Oct 1

PMID 21960179

Citations 29

Authors

Shigeru Kotake

Toru Yago

Manabu Kawamoto

Yuki Nanke

Affiliations

Soon will be listed here.

Abstract

Many papers have reported that osteoclasts play an important role in the pathogenesis of rheumatoid arthritis (RA); however, when we started to investigate the pathogenesis of RA, the roles of osteoclasts were not highlighted in RA bone resorption. In recent years, the number of articles on the roles of osteoclasts and interleukin (IL)-17 in the pathogenesis of RA has increased exponentially. In this review article, we describe our articles on the roles of osteoclasts and IL-17 in joint destruction in RA, from 1990 to 2011, and highlight a novel term, 'human osteoclastology', which we have used since 2008.

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