A Distinct Lineage of CD4 T Cells Regulates Tissue Inflammation by Producing Interleukin 17

Overview

Journal Nat Immunol

Date 2005 Oct 4

PMID 16200068

Citations 1843

Authors

Heon Park

Zhaoxia Li

Xuexian O Yang

Seon Hee Chang

Roza Nurieva

Yi-Hong Wang

Ying Wang

Leroy Hood

Zhou Zhu

Qiang Tian

Chen Dong

Affiliations

Soon will be listed here.

Abstract

Interleukin 17 (IL-17) has been linked to autoimmune diseases, although its regulation and function have remained unclear. Here we have evaluated in vitro and in vivo the requirements for the differentiation of naive CD4 T cells into effector T helper cells that produce IL-17. This process required the costimulatory molecules CD28 and ICOS but was independent of the cytokines and transcription factors required for T helper type 1 or type 2 differentiation. Furthermore, both IL-4 and interferon-gamma negatively regulated T helper cell production of IL-17 in the effector phase. In vivo, antibody to IL-17 inhibited chemokine expression in the brain during experimental autoimmune encephalomyelitis, whereas overexpression of IL-17 in lung epithelium caused chemokine production and leukocyte infiltration. Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation.

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