A Concise Stereoselective Synthesis of (-)-erycibelline
Overview
Chemistry
Affiliations
(-)-Erycibelline, the dihydroxynortropane alkaloid isolated from Erycibe elliptilimba Merr. et Chun., was synthesized using a cyclic nitrone as advanced intermediate, wherein the key step was the SmI(2)-induced intramolecular reductive coupling of cyclic nitrone with aldehyde which resulted in good yield and stereoselectivity.
General intermediates for the synthesis of 6-C-alkylated DMDP-related natural products.
Huang M, Li Y, Jia Y, Yu C Molecules. 2013; 18(6):6723-33.
PMID: 23749160 PMC: 6269708. DOI: 10.3390/molecules18066723.
Zhao H, Zhao W, Zhu J, Jia Y, Yu C Molecules. 2013; 18(5):6021-34.
PMID: 23698053 PMC: 6270483. DOI: 10.3390/molecules18056021.