Alpha 2.0
Login Register
» Articles » PMID: 21921191

Compatibility with Killer Explains the Rise of RNAi-deficient Fungi

Overview
Journal Science
Specialty Science
Date 2011 Sep 17
PMID 21921191
Citations 130
Authors
Ines A Drinnenberg
Gerald R Fink
David P Bartel
Affiliations
Soon will be listed here.
Abstract

The RNA interference (RNAi) pathway is found in most eukaryotic lineages but curiously is absent in others, including that of Saccharomyces cerevisiae. We show that reconstituting RNAi in S. cerevisiae causes loss of a beneficial double-stranded RNA virus known as killer virus. Incompatibility between RNAi and killer viruses extends to other fungal species in that RNAi is absent in all species known to possess double-stranded RNA killer viruses, whereas killer viruses are absent in closely related species that retained RNAi. Thus, the advantage imparted by acquiring and retaining killer viruses explains the persistence of RNAi-deficient species during fungal evolution.

Citing Articles

Decreased SynMuv B gene activity in response to viral infection leads to activation of the antiviral RNAi pathway in C. elegans.

Seetharaman A, Galagali H, Linarte E, Liu M, Cohen J, Chetal K PLoS Biol. 2025; 23(1):e3002748.

PMID: 39879188 PMC: 11778786. DOI: 10.1371/journal.pbio.3002748.

miRNA-target complementarity in cnidarians resembles its counterpart in plants.

Admoni Y, Fridrich A, Weavers P, Aharoni R, Razin T, Salinas-Saavedra M EMBO Rep. 2025; 26(3):836-859.

PMID: 39747665 PMC: 11811051. DOI: 10.1038/s44319-024-00350-z.

Transposon load and RNAi loss synergize to drive intraspecies diversity in .

Iracane E, Buscaino A Proc Natl Acad Sci U S A. 2024; 121(52):e2422896121.

PMID: 39680781 PMC: 11670079. DOI: 10.1073/pnas.2422896121.

The Prevalence of Killer Yeasts in the Gardens of Fungus-Growing Ants and the Discovery of Novel Killer Toxin named Ksino.

Bizarria Jr R, Creagh J, Badigian T, Correa Dos Santos R, Coss S, Tekle R bioRxiv. 2024; .

PMID: 39463942 PMC: 11507743. DOI: 10.1101/2024.10.14.618321.

SynMuv B gene activity is down-regulated during a viral infection to enhance RNA interference.

Seetharaman A, Galagali H, Linarte E, Liu M, Cohen J, Chetal K bioRxiv. 2024; .

PMID: 39071373 PMC: 11275910. DOI: 10.1101/2024.07.12.603258.

References
1.
Schmitt M, Breinig F . Yeast viral killer toxins: lethality and self-protection. Nat Rev Microbiol. 2006; 4(3):212-21. DOI: 10.1038/nrmicro1347. View
2.
Ivannikova Y, Naumova E, Naumov G . Viral dsRNA in the wine yeast Saccharomyces bayanus var. uvarum. Res Microbiol. 2007; 158(8-9):638-43. DOI: 10.1016/j.resmic.2007.07.008. View
3.
Wickner R . Double-stranded RNA viruses of Saccharomyces cerevisiae. Microbiol Rev. 1996; 60(1):250-65. PMC: 239427. DOI: 10.1128/mr.60.1.250-265.1996. View
4.
Drinnenberg I, Weinberg D, Xie K, Mower J, Wolfe K, Fink G . RNAi in budding yeast. Science. 2009; 326(5952):544-550. PMC: 3786161. DOI: 10.1126/science.1176945. View
5.
Ding S, Voinnet O . Antiviral immunity directed by small RNAs. Cell. 2007; 130(3):413-26. PMC: 2703654. DOI: 10.1016/j.cell.2007.07.039. View