Discovery of a New Class of HMG-CoA Reductase Inhibitor from Polyalthia Longifolia As Potential Lipid Lowering Agent

Overview

Journal Eur J Med Chem

Specialty Chemistry

Date 2011 Aug 30

PMID 21872367

Citations 12

Authors

Koneni V Sashidhara

Suriya P Singh

Anuj Srivastava

Anju Puri

Yashpal S Chhonker

Rabi S Bhatta

Priyanka Shah

Mohammad Imran Siddiqi

Affiliations

Soon will be listed here.

Abstract

Bioassay guided fractionation of the ethanolic extract of Polyalthia longifolia var. pendula, led to the discovery of the clerodane diterpene, 16α-hydroxycleroda-3, 13 (14) Z-dien-15, 16-olide (1), as a new structural class of HMG-CoA reductase inhibitor. Importantly, the in vivo effects of 1 corroborated well with its molecular docking analysis and also with its hamster plasma pharmacokinetics.

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