Brain Tissue Volumes by APOE Genotype and Leisure Activity-the AGES-Reykjavik Study

Overview

Journal Neurobiol Aging

Publisher Elsevier

Specialties Geriatrics
Neurology
Physiology

Date 2011 Aug 23

PMID 21856047

Citations 10

Authors

Sigridur Harpa Hafsteinsdottir

Gudny Eiriksdottir

Sigurdur Sigurdsson

Thor Aspelund

Tamara B Harris

Lenore J Launer

Vilmundur Gudnason

Affiliations

Soon will be listed here.

Abstract

This study investigates the association of the APOE ε4 allele and leisure activity with brain tissue volumes, including white matter hyperintensities (WMH), in a population-based cohort of 4303 nondemented individuals, aged 66-96 years. APOE ε4 carriers were shown to have greater WMH and cerebrospinal fluid (CSF) volumes than noncarriers but smaller gray matter (GM) volumes. There was no significant difference in white matter (WM) and total brain parenchymal (TBP) volumes between APOE ε4 carriers and noncarriers. Tests for linear trend showed that individuals with lower leisure activity levels had greater WMH and CSF volumes, smaller TBP, WM and GM volumes than those with the highest levels of participation. The significant positive trend of the leisure activity with the brain tissue volumes was observed in the APOE ε4 carriers as well as in noncarriers after adjustment for demographic and health factors. These cross-sectional data suggest leisure activity is associated with tissue volumes in the brain irrespective of the APOE ε4 risk allele status.

Citing Articles

The Relationship Between Physical Activity and Non-Modifiable Risk Factors on Alzheimer's Disease and Brain Health Markers: A UK Biobank Study.

Spencer F, Elsworthy R, Breen L, Bishop J, Morrissey S, Aldred S J Alzheimers Dis. 2024; 101(4):1029-1042.

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Depression and Dementia: The Role of Cortisol and Vascular Brain Lesions. AGES-Reykjavik Study.

Gerritsen L, Twait E, Jonsson P, Gudnason V, Launer L, Geerlings M J Alzheimers Dis. 2021; 85(4):1677-1687.

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Leisure Activities, ε4, and Cognitive Decline: A Longitudinal Cohort Study.

Zhang Y, Fu S, Ding D, Lutz M, Zeng Y, Yao Y Front Aging Neurosci. 2021; 13:736201.

PMID: 34616288 PMC: 8488387. DOI: 10.3389/fnagi.2021.736201.

Characterization of White Matter Hyperintensities in Large-Scale MRI-Studies.

Frey B, Petersen M, Mayer C, Schulz M, Cheng B, Thomalla G Front Neurol. 2019; 10:238.

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Distribution of cerebral microbleeds in the East and West: Individual participant meta-analysis.

Yakushiji Y, Wilson D, Ambler G, Charidimou A, Beiser A, van Buchem M Neurology. 2019; 92(10):e1086-e1097.

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