White Matter Lesions and Cognitive Performance: the Role of Cognitively Complex Leisure Activity

Overview

Journal J Gerontol A Biol Sci Med Sci

Specialty Geriatrics

Date 2008 Sep 6

PMID 18772473

Citations 43

Authors

Jane S Saczynski

Maria K Jonsdottir

Sigurdur Sigurdsson

Gudny Eiriksdottir

Palmi V Jonsson

Melisa E Garcia

Olafur Kjartansson

Mark A van Buchem

Vlimundur Gudnason

Lenore J Launer

Affiliations

Soon will be listed here.

Abstract

Background: Among persons with white matter lesions (WMLs), there is a range of cognitive function. We examine whether participation in leisure activities modifies the effect of WML load on cognitive function.

Methods: Data are from 2300 men and women (aged 66-92 years) participating in the population-based Age Gene/Environment Susceptibility-Reykjavik Study. Subcortical WML load was calculated as a weighted sum, based on size of lesions in the four lobes. Periventricular WML load was calculated as the sum of lesion scores, based on size, for the frontal caps, occipitoparietal caps and bands. The upper quartile of lesion load in either area was compared to the lower three quartiles. Composite scores of memory (MEM), speed of processing (SP), and executive function (EF) were constructed from a battery of neuropsychological tests. Frequency of participation in nine cognitively stimulating leisure activities was assessed via questionnaire; the upper quartile was compared to the lower three quartiles. Multiple regression, controlling for demographic and health factors and brain infarcts, was used to test the main effects and interaction of WMLs and leisure activity on cognitive function.

Results: High leisure activity was associated with higher performance in all three cognitive abilities: MEM beta = 0.20, 95% confidence interval [CI], 0.11-0.29; SP beta = 0.37, 95% CI, 0.29-0.45; and EF beta = 0.23, 95% CI, 0.15-0.29. High WML load was associated with significantly lower performance in SP (beta = -0.06, 95% CI, -0.13 to -0.01). The effect of WMLs on SP performance was modified by high leisure activity (p for interaction <.05).

Conclusion: Participation in cognitively stimulating leisure activity may attenuate the effect of WML pathology on cognitive performance.

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References

Launer L, Berger K, Breteler M, Dufouil C, Fuhrer R, Giampaoli S . Regional variability in the prevalence of cerebral white matter lesions: an MRI study in 9 European countries (CASCADE). Neuroepidemiology. 2005; 26(1):23-9. DOI: 10.1159/000089233. View

Folstein M, Folstein S, McHugh P . "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12(3):189-98. DOI: 10.1016/0022-3956(75)90026-6. View

Schneider J, Wilson R, Cochran E, Bienias J, Arnold S, Evans D . Relation of cerebral infarctions to dementia and cognitive function in older persons. Neurology. 2003; 60(7):1082-8. DOI: 10.1212/01.wnl.0000055863.87435.b2. View

Brown J, Cooper-Kuhn C, Kempermann G, van Praag H, Winkler J, Gage F . Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis. Eur J Neurosci. 2003; 17(10):2042-6. DOI: 10.1046/j.1460-9568.2003.02647.x. View

Wu C, Mungas D, Petkov C, Eberling J, Zrelak P, Buonocore M . Brain structure and cognition in a community sample of elderly Latinos. Neurology. 2002; 59(3):383-91. DOI: 10.1212/wnl.59.3.383. View

Sanchez M, Hearn E, Do D, Rilling J, Herndon J . Differential rearing affects corpus callosum size and cognitive function of rhesus monkeys. Brain Res. 1998; 812(1-2):38-49. DOI: 10.1016/s0006-8993(98)00857-9. View

Muller M, Grobbee D, Aleman A, Bots M, van der Schouw Y . Cardiovascular disease and cognitive performance in middle-aged and elderly men. Atherosclerosis. 2006; 190(1):143-9. DOI: 10.1016/j.atherosclerosis.2006.01.005. View

Agatston A, Janowitz W, HILDNER F, Zusmer N, VIAMONTE Jr M, Detrano R . Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol. 1990; 15(4):827-32. DOI: 10.1016/0735-1097(90)90282-t. View

Stern Y . What is cognitive reserve? Theory and research application of the reserve concept. J Int Neuropsychol Soc. 2002; 8(3):448-60. View

10.

Barnes D, Alexopoulos G, Lopez O, Williamson J, Yaffe K . Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study. Arch Gen Psychiatry. 2006; 63(3):273-9. DOI: 10.1001/archpsyc.63.3.273. View

11.

Bruck A, Kurki T, Kaasinen V, Vahlberg T, Rinne J . Hippocampal and prefrontal atrophy in patients with early non-demented Parkinson's disease is related to cognitive impairment. J Neurol Neurosurg Psychiatry. 2004; 75(10):1467-9. PMC: 1738757. DOI: 10.1136/jnnp.2003.031237. View

12.

Markham J, Greenough W . Experience-driven brain plasticity: beyond the synapse. Neuron Glia Biol. 2006; 1(4):351-63. PMC: 1550735. DOI: 10.1017/s1740925x05000219. View

13.

Bengtsson S, Nagy Z, Skare S, Forsman L, Forssberg H, Ullen F . Extensive piano practicing has regionally specific effects on white matter development. Nat Neurosci. 2005; 8(9):1148-50. DOI: 10.1038/nn1516. View

14.

Black J, Sirevaag A, Greenough W . Complex experience promotes capillary formation in young rat visual cortex. Neurosci Lett. 1987; 83(3):351-5. DOI: 10.1016/0304-3940(87)90113-3. View

15.

Barkhof F, Scheltens P . Imaging of white matter lesions. Cerebrovasc Dis. 2002; 13 Suppl 2:21-30. DOI: 10.1159/000049146. View

16.

Cabeza R, Anderson N, Locantore J, McIntosh A . Aging gracefully: compensatory brain activity in high-performing older adults. Neuroimage. 2002; 17(3):1394-402. DOI: 10.1006/nimg.2002.1280. View

17.

Briones T, Klintsova A, Greenough W . Stability of synaptic plasticity in the adult rat visual cortex induced by complex environment exposure. Brain Res. 2004; 1018(1):130-5. DOI: 10.1016/j.brainres.2004.06.001. View

18.

Eiriksdottir G, Aspelund T, Bjarnadottir K, Olafsdottir E, Gudnason V, Launer L . Apolipoprotein E genotype and statins affect CRP levels through independent and different mechanisms: AGES-Reykjavik Study. Atherosclerosis. 2006; 186(1):222-4. DOI: 10.1016/j.atherosclerosis.2005.12.012. View

19.

Danesh J, Wheeler J, Hirschfield G, Eda S, Eiriksdottir G, Rumley A . C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med. 2004; 350(14):1387-97. DOI: 10.1056/NEJMoa032804. View

20.

Launer L . Epidemiology of white-matter lesions. Int Psychogeriatr. 2005; 15 Suppl 1:99-103. DOI: 10.1017/S1041610203009037. View