Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Disease

Overview

Journal Int J Med Sci

Specialty General Medicine

Date 2011 Aug 19

PMID 21850195

Citations 19

Authors

Aysegul Cebi

Yuksel Kaya

Hasan Gungor

Halit Demir

Ibrahim Hakki Yoruk

Nihat Soylemez

Yilmaz Gunes

Mustafa Tuncer

Affiliations

Soon will be listed here.

Abstract

Aim: In the present study, we aimed to assess serum concentrations of zinc (Zn), copper (Cu), iron (Fe), cadmium (Cd), lead (Pb), manganese (Mn), vitamins A (retinol), D (cholecalciferol) and E (α-tocopherol) in patients with coronary artery disease (CAD) and to compare with healthy controls.

Methods: A total of 30 CAD patients and 20 healthy subjects were included in this study. Atomic absorption spectrophotometry (UNICAM-929) was used to measure heavy metal and trace element concentrations. Serum α-tocopherol, retinol and cholecalciferol were measured simultaneously by high performance liquid chromatography (HPLC).

Results: Demographic and baseline clinical characteristics were not statistically different between the groups. Serum concentrations of retinol (0.3521 ± 0.1319 vs. 0.4313 ± 0.0465 mmol/I, p=0.013), tocopherol (3.8630 ± 1.3117 vs. 6.9124 ± 1.0577 mmol/I, p<0.001), cholecalciferol (0.0209 ± 0.0089 vs. 0.0304±0.0059 mmol/I, p<0.001) and Fe (0.5664 ± 0.2360 vs. 1.0689 ± 0,4452 µg/dI, p<0.001) were significantly lower in CAD patients. In addition, while not statistically significant serum Cu (1.0164 ± 0.2672 vs. 1.1934 ± 0.4164 µg/dI, p=0.073) concentrations were tended to be lower in patients with CAD, whereas serum lead (0.1449 ± 0.0886 vs. 0.1019 ± 0.0644 µg/dI, p=0.069) concentrations tended to be higher.

Conclusions: Serum level of trace elements and vitamins may be changed in patients with CAD. In this relatively small study we found that serum levels of retinol, tocopherol, cholecalciferol, iron and copper may be lower whereas serum lead concentrations may be increased in patients with CAD.

Citing Articles

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Research trends in the relationship between vitamin D and type 2 diabetes mellitus: a 20-year bibliometric and visualization analysis.

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The relationship between serum manganese concentration with all-cause and cause-specific mortality: a retrospective and population-based cross-sectional study.

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Assessment and Exposure Analysis of Trace Metals in Different Age Groups of the Male Population in Southern Punjab, Pakistan.

Hussain S, Khanam T, Ullah S, Aziz F, Sattar A, Hussain I Toxics. 2023; 11(12).

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References

Zaspel B, Csallany A . Determination of alpha-tocopherol in tissues and plasma by high-performance liquid chromatography. Anal Biochem. 1983; 130(1):146-50. DOI: 10.1016/0003-2697(83)90661-9. View

Reunanen A, Takkunen H, Knekt P, Seppanen R, Aromaa A . Body iron stores, dietary iron intake and coronary heart disease mortality. J Intern Med. 1995; 238(3):223-30. DOI: 10.1111/j.1365-2796.1995.tb00926.x. View

Tuomainen T, Punnonen K, Nyyssonen K, Salonen J . Association between body iron stores and the risk of acute myocardial infarction in men. Circulation. 1998; 97(15):1461-6. DOI: 10.1161/01.cir.97.15.1461. View

Omenn G, Goodman G, Thornquist M, Balmes J, Cullen M, Glass A . Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 1996; 334(18):1150-5. DOI: 10.1056/NEJM199605023341802. View

Miller K, Yang C . An isocratic high-performance liquid chromatography method for the simultaneous analysis of plasma retinol, alpha-tocopherol, and various carotenoids. Anal Biochem. 1985; 145(1):21-6. DOI: 10.1016/0003-2697(85)90321-5. View

Wang T, Pencina M, Booth S, Jacques P, Ingelsson E, Lanier K . Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008; 117(4):503-11. PMC: 2726624. DOI: 10.1161/CIRCULATIONAHA.107.706127. View

Navas-Acien A, Guallar E, Silbergeld E, Rothenberg S . Lead exposure and cardiovascular disease--a systematic review. Environ Health Perspect. 2007; 115(3):472-82. PMC: 1849948. DOI: 10.1289/ehp.9785. View

Doherty T, Tang W, Dascalos S, Watson K, Demer L, Shavelle R . Ethnic origin and serum levels of 1alpha,25-dihydroxyvitamin D3 are independent predictors of coronary calcium mass measured by electron-beam computed tomography. Circulation. 1997; 96(5):1477-81. DOI: 10.1161/01.cir.96.5.1477. View

Steinberg D . Antioxidant vitamins and coronary heart disease. N Engl J Med. 1993; 328(20):1487-9. DOI: 10.1056/NEJM199305203282012. View

10.

Scragg R, Jackson R, Holdaway I, Lim T, Beaglehole R . Myocardial infarction is inversely associated with plasma 25-hydroxyvitamin D3 levels: a community-based study. Int J Epidemiol. 1990; 19(3):559-63. DOI: 10.1093/ije/19.3.559. View

11.

Ames B, Shigenaga M, Hagen T . Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A. 1993; 90(17):7915-22. PMC: 47258. DOI: 10.1073/pnas.90.17.7915. View

12.

Watson K, Abrolat M, Malone L, Hoeg J, Doherty T, Detrano R . Active serum vitamin D levels are inversely correlated with coronary calcification. Circulation. 1997; 96(6):1755-60. DOI: 10.1161/01.cir.96.6.1755. View

13.

Ascherio A, Rimm E, Giovannucci E, Willett W, Stampfer M . Blood donations and risk of coronary heart disease in men. Circulation. 2001; 103(1):52-7. DOI: 10.1161/01.cir.103.1.52. View

14.

Yusoff K . Vitamin E in cardiovascular disease: has the die been cast?. Asia Pac J Clin Nutr. 2002; 11 Suppl 7:S443-7. DOI: 10.1046/j.1440-6047.11.s.7.11.x. View

15.

Liao Y, Cooper R, McGee D . Iron status and coronary heart disease: negative findings from the NHANES I epidemiologic follow-up study. Am J Epidemiol. 1994; 139(7):704-12. DOI: 10.1093/oxfordjournals.aje.a117060. View

16.

Rock E, Winklhofer-Roob B, Ribalta J, Scotter M, Vasson M, Brtko J . Vitamin A, vitamin E and carotenoid status and metabolism during ageing: functional and nutritional consequences (VITAGE PROJECT). Nutr Metab Cardiovasc Dis. 2002; 11(4 Suppl):70-3. View

17.

Malabanan A, Veronikis I, Holick M . Redefining vitamin D insufficiency. Lancet. 1998; 351(9105):805-6. DOI: 10.1016/s0140-6736(05)78933-9. View

18.

Yavuz B, Ertugrul D, Cil H, Ata N, Akin K, Yalcin A . Increased levels of 25 hydroxyvitamin D and 1,25-dihydroxyvitamin D after rosuvastatin treatment: a novel pleiotropic effect of statins?. Cardiovasc Drugs Ther. 2009; 23(4):295-9. DOI: 10.1007/s10557-009-6181-8. View

19.

VOLKOV N . [The cobalt, manganese and zinc content in the blood and internal organs of atherosclerotic patients]. Ter Arkh. 1962; 34:52-6. View

20.

Rimm E, Stampfer M, Ascherio A, Giovannucci E, Colditz G, Willett W . Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med. 1993; 328(20):1450-6. DOI: 10.1056/NEJM199305203282004. View