Amelioration of Lipid Abnormalities by Vitamin Therapy in Women Using Oral Contraceptives

Overview

Journal Clin Exp Reprod Med

Date 2014 Apr 3

PMID 24693493

Citations 1

Authors

Shahnaz TorkZahrani

Afrooz Heidari

Zohreh Mostafavi-Pour

Majid Ahmadi

Fatemeh Zal

Affiliations

Soon will be listed here.

Abstract

Objective: Combined oral contraceptives (COCs) have some adverse effects on the serum lipid profile. Because hyperlipidemia is one of the risk factors in cardiovascular diseases, lipid abnormalities should be evaluated in women consuming COCs. Vitamins E and C are known to have beneficial effects on serum lipid profiles. Therefore, in this study, we evaluated the effects of vitamins E and C on serum lipids in women using COCs.

Methods: The study compared changes in lipid parameters with and without vitamin therapy in women consuming COCs compared to those of a control group (40 non-contraceptive users or NCU) for 4 weeks. Total cholesterol and triglyceride, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels along with HDL/LDL ratios were measured for all participants.

Results: COC users experienced significantly higher increases in the levels of triglycerides and LDL than non-users (p<0.05). However, no significant differences were noted in the total cholesterol and HDL levels. In the treated COC group receiving vitamins E and C, the HDL level and the HDL/LDL ratio increased and the LDL and triglycerides levels decreased significantly compared with those of the other groups.

Conclusion: The results of our study indicate that supplementation with antioxidant vitamins E and C restores a normal lipid profile in COC users.

Citing Articles

Oral Contraceptive Use May Modulate Global Genomic DNA Methylation and Promoter Methylation of APC1 and ESR1.

Moradi Sarabi M, Ghareghani P, Khademi F, Zal F Asian Pac J Cancer Prev. 2017; 18(9):2361-2366.

PMID: 28950679 PMC: 5720637. DOI: 10.22034/APJCP.2017.18.9.2361.

References

Margolis K, Adami H, Luo J, Ye W, Weiderpass E . A prospective study of oral contraceptive use and risk of myocardial infarction among Swedish women. Fertil Steril. 2007; 88(2):310-6. DOI: 10.1016/j.fertnstert.2006.11.206. View

Li Y, Wang C, Zhu K, Feng R, Sun C . Effects of multivitamin and mineral supplementation on adiposity, energy expenditure and lipid profiles in obese Chinese women. Int J Obes (Lond). 2010; 34(6):1070-7. DOI: 10.1038/ijo.2010.14. View

Grigoryan O, Grodnitskaya E, Andreeva E, Shestakova M, Melnichenko G, Dedov I . Contraception in perimenopausal women with diabetes mellitus. Gynecol Endocrinol. 2006; 22(4):198-206. DOI: 10.1080/09513590600624317. View

Riccioni G, DOrazio N, Salvatore C, Franceschelli S, Pesce M, Speranza L . Carotenoids and vitamins C and E in the prevention of cardiovascular disease. Int J Vitam Nutr Res. 2012; 82(1):15-26. DOI: 10.1024/0300-9831/a000090. View

DeFilippis A, Blaha M, Martin S, Reed R, Jones S, Nasir K . Nonalcoholic fatty liver disease and serum lipoproteins: the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis. 2013; 227(2):429-36. PMC: 4049078. DOI: 10.1016/j.atherosclerosis.2013.01.022. View

Rao V, Kiran R . Evaluation of correlation between oxidative stress and abnormal lipid profile in coronary artery disease. J Cardiovasc Dis Res. 2011; 2(1):57-60. PMC: 3120274. DOI: 10.4103/0975-3583.78598. View

Holdcroft C . Combined oral contraceptive pills: a brief review. Nurse Pract. 1994; 19(11):5, 11-2, 15. DOI: 10.1097/00006205-199411000-00001. View

Dilbaz B, Ozdegirmenci O, Caliskan E, Dilbaz S, Haberal A . Effect of etonogestrel implant on serum lipids, liver function tests and hemoglobin levels. Contraception. 2010; 81(6):510-4. DOI: 10.1016/j.contraception.2010.01.014. View

Skouby S, Endrikat J, Dusterberg B, Schmidt W, Gerlinger C, Wessel J . A 1-year randomized study to evaluate the effects of a dose reduction in oral contraceptives on lipids and carbohydrate metabolism: 20 microg ethinyl estradiol combined with 100 microg levonorgestrel. Contraception. 2005; 71(2):111-7. DOI: 10.1016/j.contraception.2004.08.017. View

10.

Berneis K, Jeanneret C, Muser J, Felix B, Miserez A . Low-density lipoprotein size and subclasses are markers of clinically apparent and non-apparent atherosclerosis in type 2 diabetes. Metabolism. 2005; 54(2):227-34. DOI: 10.1016/j.metabol.2004.08.017. View

11.

Minozzi M, Costantino D, Guaraldi C, Unfer V . The effect of a combination therapy with myo-inositol and a combined oral contraceptive pill versus a combined oral contraceptive pill alone on metabolic, endocrine, and clinical parameters in polycystic ovary syndrome. Gynecol Endocrinol. 2011; 27(11):920-4. DOI: 10.3109/09513590.2011.564685. View

12.

Duvillard L, Dautin G, Florentin E, Petit J, Gambert P, Verges B . Changes in apolipoprotein B100-containing lipoprotein metabolism due to an estrogen plus progestin oral contraceptive: a stable isotope kinetic study. J Clin Endocrinol Metab. 2010; 95(5):2140-6. DOI: 10.1210/jc.2009-2480. View

13.

Marchetti C, Sidahmed-Adrar N, Collin F, Jore D, Gardes-Albert M, Bonnefont-Rousselot D . Melatonin protects PLPC liposomes and LDL towards radical-induced oxidation. J Pineal Res. 2011; 51(3):286-96. DOI: 10.1111/j.1600-079X.2011.00889.x. View

14.

Plu-Bureau G, Hugon-Rodin J, Maitrot-Mantelet L, Canonico M . Hormonal contraceptives and arterial disease: an epidemiological update. Best Pract Res Clin Endocrinol Metab. 2013; 27(1):35-45. DOI: 10.1016/j.beem.2012.11.003. View

15.

Cebi A, Kaya Y, Gungor H, Demir H, Yoruk I, Soylemez N . Trace elements, heavy metals and vitamin levels in patients with coronary artery disease. Int J Med Sci. 2011; 8(6):456-60. PMC: 3156992. DOI: 10.7150/ijms.8.456. View

16.

Kemmeren J, Algra A, Meijers J, Tans G, Bouma B, Curvers J . Effect of second- and third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial. Blood. 2003; 103(3):927-33. DOI: 10.1182/blood-2003-04-1285. View

17.

Berenson A, Rahman M, Wilkinson G . Effect of injectable and oral contraceptives on serum lipids. Obstet Gynecol. 2009; 114(4):786-794. PMC: 2853747. DOI: 10.1097/AOG.0b013e3181b76bea. View

18.

Taneepanichskul S, Phupong V . Influence of a new oral contraceptive with drospirenone on lipid metabolism. Gynecol Endocrinol. 2007; 23(6):347-50. DOI: 10.1080/09513590701325731. View

19.

Golbidi S, Ebadi S, Laher I . Antioxidants in the treatment of diabetes. Curr Diabetes Rev. 2011; 7(2):106-25. DOI: 10.2174/157339911794940729. View

20.

Huang H, Appel L, Croft K, Miller 3rd E, Mori T, Puddey I . Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trial. Am J Clin Nutr. 2002; 76(3):549-55. DOI: 10.1093/ajcn/76.3.549. View