MicroRNA Networks Direct Neuronal Development and Plasticity

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2011 Aug 12

PMID 21833581

Citations 110

Authors

N F M Olde Loohuis

A Kos

G J M Martens

H van Bokhoven

N Nadif Kasri

A Aschrafi

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) constitute a class of small, non-coding RNAs that act as post-transcriptional regulators of gene expression. In neurons, the functions of individual miRNAs are just beginning to emerge, and recent studies have elucidated roles for neural miRNAs at various stages of neuronal development and maturation, including neurite outgrowth, dendritogenesis, and spine formation. Notably, miRNAs regulate mRNA translation locally in the axosomal and synaptodendritic compartments, and thereby contribute to the dynamic spatial organization of axonal and dendritic structures and their function. Given the critical role for miRNAs in regulating early brain development and in mediating synaptic plasticity later in life, it is tempting to speculate that the pathology of neurological disorders is affected by altered expression or functioning of miRNAs. Here we provide an overview of recently identified mechanisms of neuronal development and plasticity involving miRNAs, and the consequences of miRNA dysregulation.

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References

Gao J, Wang W, Mao Y, Graff J, Guan J, Pan L . A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature. 2010; 466(7310):1105-9. PMC: 2928875. DOI: 10.1038/nature09271. View

Montag J, Hitt R, Opitz L, Schulz-Schaeffer W, Hunsmann G, Motzkus D . Upregulation of miRNA hsa-miR-342-3p in experimental and idiopathic prion disease. Mol Neurodegener. 2009; 4:36. PMC: 2743691. DOI: 10.1186/1750-1326-4-36. View

Abelson J, Kwan K, ORoak B, Baek D, Stillman A, Morgan T . Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science. 2005; 310(5746):317-20. DOI: 10.1126/science.1116502. View

Bruno I, Karam R, Huang L, Bhardwaj A, Lou C, Shum E . Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay. Mol Cell. 2011; 42(4):500-10. PMC: 3123134. DOI: 10.1016/j.molcel.2011.04.018. View

Leung K, van Horck F, Lin A, Allison R, Standart N, Holt C . Asymmetrical beta-actin mRNA translation in growth cones mediates attractive turning to netrin-1. Nat Neurosci. 2006; 9(10):1247-56. PMC: 1997306. DOI: 10.1038/nn1775. View

Roush S, Slack F . The let-7 family of microRNAs. Trends Cell Biol. 2008; 18(10):505-16. DOI: 10.1016/j.tcb.2008.07.007. View

Ming G, Wong S, Henley J, Yuan X, Song H, Spitzer N . Adaptation in the chemotactic guidance of nerve growth cones. Nature. 2002; 417(6887):411-8. DOI: 10.1038/nature745. View

Beveridge N, Tooney P, Carroll A, Gardiner E, Bowden N, Scott R . Dysregulation of miRNA 181b in the temporal cortex in schizophrenia. Hum Mol Genet. 2008; 17(8):1156-68. DOI: 10.1093/hmg/ddn005. View

Fiore R, Khudayberdiev S, Christensen M, Siegel G, Flavell S, Kim T . Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. EMBO J. 2009; 28(6):697-710. PMC: 2647767. DOI: 10.1038/emboj.2009.10. View

10.

Konopka W, Kiryk A, Novak M, Herwerth M, Parkitna J, Wawrzyniak M . MicroRNA loss enhances learning and memory in mice. J Neurosci. 2010; 30(44):14835-42. PMC: 6633640. DOI: 10.1523/JNEUROSCI.3030-10.2010. View

11.

Packer A, Xing Y, Harper S, Jones L, Davidson B . The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease. J Neurosci. 2009; 28(53):14341-6. PMC: 3124002. DOI: 10.1523/JNEUROSCI.2390-08.2008. View

12.

Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L . miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev. 2002; 16(6):720-8. PMC: 155365. DOI: 10.1101/gad.974702. View

13.

Davis T, Cuellar T, Koch S, Barker A, Harfe B, McManus M . Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci. 2008; 28(17):4322-30. PMC: 3844796. DOI: 10.1523/JNEUROSCI.4815-07.2008. View

14.

Vo N, Klein M, Varlamova O, Keller D, Yamamoto T, Goodman R . A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc Natl Acad Sci U S A. 2005; 102(45):16426-31. PMC: 1283476. DOI: 10.1073/pnas.0508448102. View

15.

Belmonte M, Allen G, Beckel-Mitchener A, Boulanger L, Carper R, Webb S . Autism and abnormal development of brain connectivity. J Neurosci. 2004; 24(42):9228-31. PMC: 6730085. DOI: 10.1523/JNEUROSCI.3340-04.2004. View

16.

De Pietri Tonelli D, Pulvers J, Haffner C, Murchison E, Hannon G, Huttner W . miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex. Development. 2008; 135(23):3911-21. PMC: 2798592. DOI: 10.1242/dev.025080. View

17.

Aschrafi A, Natera-Naranjo O, Gioio A, Kaplan B . Regulation of axonal trafficking of cytochrome c oxidase IV mRNA. Mol Cell Neurosci. 2010; 43(4):422-30. PMC: 2845174. DOI: 10.1016/j.mcn.2010.01.009. View

18.

Park C, Tang S . Regulation of microRNA expression by induction of bidirectional synaptic plasticity. J Mol Neurosci. 2008; 38(1):50-6. DOI: 10.1007/s12031-008-9158-3. View

19.

Beaumont V, Zhong N, Fletcher R, Froemke R, Zucker R . Phosphorylation and local presynaptic protein synthesis in calcium- and calcineurin-dependent induction of crayfish long-term facilitation. Neuron. 2001; 32(3):489-501. DOI: 10.1016/s0896-6273(01)00483-4. View

20.

Siegel G, Obernosterer G, Fiore R, Oehmen M, Bicker S, Christensen M . A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat Cell Biol. 2009; 11(6):705-16. PMC: 3595613. DOI: 10.1038/ncb1876. View