General Aspects of Metal Ions As Signaling Agents in Health and Disease

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2020 Oct 10

PMID 33036384

Citations 17

Authors

Karolina Krzywoszynska

Danuta Witkowska

Jolanta Swiatek-Kozlowska

Agnieszka Szebesczyk

Henryk Kozlowski

Affiliations

Soon will be listed here.

Abstract

This review focuses on the current knowledge on the involvement of metal ions in signaling processes within the cell, in both physiological and pathological conditions. The first section is devoted to the recent discoveries on magnesium and calcium-dependent signal transduction-the most recognized signaling agents among metals. The following sections then describe signaling pathways where zinc, copper, and iron play a key role. There are many systems in which changes in intra- and extra-cellular zinc and copper concentrations have been linked to important downstream events, especially in nervous signal transduction. Iron signaling is mostly related with its homeostasis. However, it is also involved in a recently discovered type of programmed cell death, ferroptosis. The important differences in metal ion signaling, and its disease-leading alterations, are also discussed.

Citing Articles

The PACT Network: PRL, ARL, CNNM, and TRPM Proteins in Magnesium Transport and Disease.

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Multifaceted Sulfonamide-Derived Thiosemicarbazones: Combining Metal Chelation and Carbonic Anhydrases Inhibition in Anticancer Therapy.

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Design of a light and Ca switchable organic-peptide hybrid.

Khaleel Z, No Y, Kim N, Bae D, Wu Y, Kim S Proc Natl Acad Sci U S A. 2025; 122(5):e2411316122.

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Impact of Metal Ions on Cellular Functions: A Focus on Mesenchymal Stem/Stromal Cell Differentiation.

Peters K, Staehlke S, Rebl H, Jonitz-Heincke A, Hahn O Int J Mol Sci. 2024; 25(18).

PMID: 39337612 PMC: 11432215. DOI: 10.3390/ijms251810127.

The interplay of transition metals in ferroptosis and pyroptosis.

Vana F, Szabo Z, Masarik M, Kratochvilova M Cell Div. 2024; 19(1):24.

PMID: 39097717 PMC: 11297737. DOI: 10.1186/s13008-024-00127-9.

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