A Biomarker Survey of Urinary Deoxynivalenol in China: the Shanghai Women's Health Study

Overview

Journal Food Addit Contam Part A Chem Anal Control Expo Risk Assess

Publisher Informa Healthcare

Specialty Nutritional Sciences

Date 2011 Jul 22

PMID 21774617

Citations 11

Authors

P C Turner

B T Ji

X O Shu

W Zheng

W H Chow

Y T Gao

L J Hardie

Affiliations

Soon will be listed here.

Abstract

Deoxynivalenol (DON) is a trichothecene mycotoxin found on wheat, maize and barley. In ecological surveys in China, DON and other trichothecenes have been implicated in acute poisoning episodes and linked with the incidence of esophageal cancer. In order to better understand exposure patterns, this pilot survey provided a combined measure of urinary un-metabolised or free DON (fD) and its glucuronide metabolite (DG) in a subset of 60 samples taken from the Shanghai Women's Health Study cohort, China. Samples were collected in 1997/1998 from women age 40-70 years. Urinary fD+DG combined was detected in 58/60 (96.7%) samples (mean 5.9 ng DON/mg creatinine; range nd-30.5); a similar frequency, and a mean level approximately half, of that previously observed for women in the UK. Wheat consumption was approximately 25% of that consumed by western diets; thus DON contamination of wheat may be higher in Shanghai than the UK. The de-epoxy metabolite of DON, a detoxification product observed in animals, was not detected, suggesting that humans may be particularly sensitive to DON due to a more restricted detoxification capacity.

Citing Articles

Human biomonitoring of deoxynivalenol (DON) - Assessment of the exposure of young German adults from 1996 - 2021.

Schmied A, Marske L, Berger M, Kujath P, Weber T, Kolossa-Gehring M Int J Hyg Environ Health. 2023; 252:114198.

PMID: 37311395 PMC: 10410250. DOI: 10.1016/j.ijheh.2023.114198.

Mycotoxins-Biomonitoring and Human Exposure.

Habschied K, Kanizai Saric G, Krstanovic V, Mastanjevic K Toxins (Basel). 2021; 13(2).

PMID: 33546479 PMC: 7913644. DOI: 10.3390/toxins13020113.

Dietary Deoxynivalenol Exposure Assessment in University Students from Japan.

Xia L, Sugita-Konishi Y, Gong Y, Routledge M Food Saf (Tokyo). 2020; 7(2):48-53.

PMID: 31998586 PMC: 6978884. DOI: 10.14252/foodsafetyfscj.2018021.

Determination of Deoxynivalenol Biomarkers in Italian Urine Samples.

De Santis B, Debegnach F, Miano B, Moretti G, Sonego E, Chiaretti A Toxins (Basel). 2019; 11(8).

PMID: 31349679 PMC: 6722612. DOI: 10.3390/toxins11080441.

Risk assessment of deoxynivalenol in high-risk area of China by human biomonitoring using an improved high throughput UPLC-MS/MS method.

Deng C, Li C, Zhou S, Wang X, Xu H, Wang D Sci Rep. 2018; 8(1):3901.

PMID: 29497102 PMC: 5832810. DOI: 10.1038/s41598-018-22206-y.

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