Complex Biotransformations Catalyzed by Radical S-adenosylmethionine Enzymes

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2011 Jul 21

PMID 21771780

Citations 12

Authors

Qi Zhang

Wen Liu

Affiliations

Soon will be listed here.

Abstract

The radical S-adenosylmethionine (AdoMet) superfamily currently comprises thousands of proteins that participate in numerous biochemical processes across all kingdoms of life. These proteins share a common mechanism to generate a powerful 5'-deoxyadenosyl radical, which initiates a highly diverse array of biotransformations. Recent studies are beginning to reveal the role of radical AdoMet proteins in the catalysis of highly complex and chemically unusual transformations, e.g. the ThiC-catalyzed complex rearrangement reaction. The unique features and intriguing chemistries of these proteins thus demonstrate the remarkable versatility and sophistication of radical enzymology.

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