The Tuberous Sclerosis Complex-mammalian Target of Rapamycin Pathway Maintains the Quiescence and Survival of Naive T Cells

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 2011 Jun 29

PMID 21709159

Citations 55

Authors

Qi Wu

Yu Liu

Chong Chen

Tsuneo Ikenoue

Yu Qiao

Chi-Shan Li

Weiquan Li

Kun-Liang Guan

Yang Liu

Pan Zheng

Affiliations

Soon will be listed here.

Abstract

Naive T cells receive stimulation from the positive selecting ligand in the periphery for their survival. This stimulation does not normally lead to overt activation of T cells, as the T cells remain largely quiescent until they receive either antigenic or lymphopenic stimuli. The underlying mechanism responsible for survival and quiescence of the naive T cells remains largely unknown. In this study, we report that T cell-specific deletion of Tsc1, a negative regulator of mammalian target of rapamycin, resulted in both spontaneous losses of quiescence and cellularity, especially within the CD8 subset. The Tsc1-deficient T cells have increased cell proliferation and apoptosis. Tsc1 deletion affects the survival and quiescence of T cells in the absence of antigenic stimulation. Loss of quiescence but not cellularity was inhibited by rapamycin. Our data demonstrate that tuberous sclerosis complex-mammalian target of rapamycin maintains quiescence and survival of T cells.

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