MTOR Signaling in the Differentiation and Function of Regulatory and Effector T Cells

Overview

Journal Curr Opin Immunol

Publisher Elsevier

Specialty Allergy & Immunology

Date 2017 May 24

PMID 28535458

Citations 94

Authors

Hu Zeng

Hongbo Chi

Affiliations

Soon will be listed here.

Abstract

The mechanistic target of rapamycin (mTOR) signaling pathway integrates environmental signals and cellular metabolism to regulate T cell development, activation and differentiation. Recent studies reveal the importance of exquisite control of mTOR activity for proper T cell function, and detailed molecular mechanisms that regulate mTOR signaling in different T cell subsets. Here, we review the latest advances in our understanding of the mTOR pathway and its regulation in the differentiation and function of regulatory T cells and effector T cells.

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