Inhibition of Cell-mediated Cytolysis of Trinitrophenyl-derivatized Target Cells by Alloantisera Directed to the Products of the K and D Loci of the H-2 Complex

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1976 Feb 1

PMID 1082140

Citations 26

Authors

S J Burakoff

R N Germain

M E Dorf

B Benacerrah

Affiliations

Soon will be listed here.

Abstract

The role of the products of the K and D loci of the H-2 complex as target antigens for cytotoxic T cells generated to modified syngeneic cells has been investigated. Spleen cells, when cocultured with trinitrophenyl-derivatized syngeneic cells, generate cytolytic T cells that lyse most effectively tumor or spleen targets that are trinitrophenyl-derivatized and H-2 identical to the sensitizing cell. Cytolysis is inhibited by alloantisera to the K and/or D specificities of the target cells and by anti-dinitrophenyl antisera. Cytolic cells generated in this manner are also able to lyse, though less efficiently, trinitrophenyl-derivatized tumor and spleen targets that do not share products of the K and D loci with the sensitizing cell, and this cytolysis is also blocked by alloantisera directed to the H-2 serological specificities of such targets.

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