Gold Nanoparticle-mediated Gene Delivery Induces Widespread Changes in the Expression of Innate Immunity Genes

Overview

Journal Gene Ther

Date 2011 Jun 24

PMID 21697957

Citations 18

Authors

E-Y Kim

R Schulz

P Swantek

K Kunstman

M H Malim

S M Wolinsky

Affiliations

Soon will be listed here.

Abstract

The unique properties of oligonucleotide (and small interfering RNA)-modified gold nanoparticle conjugates make them promising intracellular gene regulation agents. We found that gold nanoparticles stably functionalized with covalently attached oligonucleotides activate immune-related genes and pathways in human peripheral blood mononuclear cells, but not an immortalized, lineage-restricted cell line. These findings have strong implications for the application of oligonucleotide-modified gold nanoparticle conjugates in translational research and in the development of therapeutics and gene delivery systems.

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