Intracellular DNA Recognition

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2010 Jan 26

PMID 20098460

Citations 190

Authors

Veit Hornung

Eicke Latz

Affiliations

Soon will be listed here.

Abstract

The recognition of nucleic acids is one strategy by which cells can detect infectious agents. As life is ultimately determined by the existence of nucleic acids, this defence strategy has evolved in many different organisms and operates effectively in many different cell types. Here, we review the recent progress in our understanding of the molecular mechanisms by which DNA activates cells to induce inflammation and antimicrobial immunity. DNA can be detected in different cellular compartments and can induce a range of cellular responses, such as an antiviral response and pyroptotic cell death together with the maturation and release of active interleukin-1beta.

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