Native N-glycopeptide Thioester Synthesis Through N→S Acyl Transfer

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2011 Jun 17

PMID 21676613

Citations 3

Authors

Bhavesh Premdjee

Anna L Adams

Derek Macmillan

Affiliations

Soon will be listed here.

Abstract

Peptide thioesters are important tools for the total synthesis of proteins using native chemical ligation (NCL). Preparation of glycopeptide thioesters, that enable the assembly of homogeneously glycosylated proteins, is complicated by the perceived fragile nature of the sugar moiety. Herein, we demonstrate the compatibility of thioester formation via N→S acyl transfer with native N-glycopeptides and report observations that will aid in their preparation.

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