Recent Departures in the Synthesis of Peptides and Glycopeptides

Overview

Journal Tetrahedron

Specialty Chemistry

Date 2010 Feb 18

PMID 20161377

Citations 16

Authors

Cindy Kan

Samuel J Danishefsky

Affiliations

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Abstract

In this account, we describe the results of a research program directed to the proposition that chemical synthesis can play a valuable role in identifying biologic level molecules worthy of pharma level development. We recount our journey towards the chemical synthesis of homogeneous erythropoietin, the challenges we encountered, and our efforts to address deficiencies in the current "state of the art" of glycopeptide synthesis. Here we describe new methods for the synthesis of glycopeptides that have emerged from the erythropoietin adventure, including the development of unique C-terminal acyl donors, novel amide bond forming methods, and new ligation and coupling strategies.

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