Simian Immunodeficiency Virus Infection in Rhesus Macaques Induces Selective Tissue Specific B Cell Defects in Double Positive CD21+CD27+ Memory B Cells

Overview

Journal Clin Immunol

Specialty Allergy & Immunology

Date 2011 May 31

PMID 21622026

Citations 20

Authors

Arpita Das

Ronald S Veazey

Xiaolei Wang

Andrew A Lackner

Huanbin Xu

Bapi Pahar

Affiliations

Soon will be listed here.

Abstract

B cell dysfunction represents a central feature in HIV infection and pathogenesis. Our recent studies have shown that peripheral and lymphoid double positive CD21+CD27+ B cells were able to become activated and proliferate at higher rates than other B cell subpopulations. Increased proliferation of tonsillar memory B cells was identified compared to other tissues examined. Here, we demonstrate the decreased proliferation of tonsillar memory (CD21+CD27+) B cells during acute SIV infection also suggests that these cells may play an important role in SIV pathogenesis. Our findings demonstrate that SIV infection may induce selective defective responses in specific tissues, by suppressing memory B cell proliferation in tissues.

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