Idiopathic CD4+ T Lymphocytopenia is Associated with Increases in Immature/transitional B Cells and Serum Levels of IL-7

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2006 Oct 21

PMID 17053062

Citations 54

Authors

Angela Malaspina

Susan Moir

Doreen G Chaitt

Catherine A Rehm

Shyam Kottilil

Judith Falloon

Anthony S Fauci

Affiliations

Soon will be listed here.

Abstract

Idiopathic CD4+ T lymphocytopenia (ICL) is a rare heterogeneous disorder defined by CD4+ T-cell counts below 300 cells/muL in the absence of human immunodeficiency virus (HIV) infection or other known immune deficiency disorders. Here, we report the expansion of immature/transitional B cells in patients with ICL, which is associated with elevated serum levels of IL-7. Both the percentage of immature/transitional B cells and levels of IL-7 were inversely correlated with levels of CD4+ T-cell counts and directly correlated to each other. Further analyses of B cells indicated that, in contrast to the activating effects of HIV disease on mature B cells, the expansion of immature/transitional B cells in patients with ICL occurred at the expense of memory B cells. These findings extend previous reports on primary immunodeficiencies as well as HIV disease by suggesting that CD4+ T-cell lymphopenia has an impact on human B-cell development either directly or indirectly via the associated elevation of IL-7 levels.

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