Xenotransplantation of Cryopreserved Ovarian Tissue from Patients with Ovarian Tumors into SCID Mice--no Evidence of Malignant Cell Contamination

Overview

Journal Fertil Steril

Specialty Reproductive Medicine

Date 2011 May 31

PMID 21621205

Citations 14

Authors

Laura Lotz

Markus Montag

Hans van der Ven

Michael von Wolff

Andreas Mueller

Inge Hoffmann

David Wachter

Matthias W Beckmann

Ralf Dittrich

Affiliations

Soon will be listed here.

Abstract

This study examined the possible presence of malignant cells in ovarian cortex from patients with ovarian tumors after xenografting of the ovarian tissue into severe combined immunodeficiency mice. None of the mice presented symptoms of reintroduced malignancy nor did microscopic and immunohistochemical evaluation of the grafts raise any suspicion of residual malignant disease.

Citing Articles

Evaluating the safety and efficacy of cryopreserved ovarian tissue transplantation in leukemia patients with different bone marrow remission status using xenotransplantation.

Li Y, Ruan X, Gu M, Du J, Jin F, Cheng J Front Endocrinol (Lausanne). 2024; 15:1364316.

PMID: 38590823 PMC: 10999602. DOI: 10.3389/fendo.2024.1364316.

Comparative analysis of two cryopreservation systems of ovarian tissues in female Wistar rats.

Durli I, Paz A, Terraciano P, Passos E, Cirne-Lima E JBRA Assist Reprod. 2022; 18(1):7-11.

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Molecular Mechanism and Prevention Strategy of Chemotherapy- and Radiotherapy-Induced Ovarian Damage.

Kim S, Kim S, Han S, Lee S, Park H, Song J Int J Mol Sci. 2021; 22(14).

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Development of Ovarian Tissue Autograft to Restore Ovarian Function: Protocol for a French Multicenter Cohort Study.

Pretalli J, Frontczak Franck S, Pazart L, Roux C, Amiot C JMIR Res Protoc. 2019; 8(9):e12944.

PMID: 31573931 PMC: 6802486. DOI: 10.2196/12944.

Ovarian Tissue Transplantation: Experience From Germany and Worldwide Efficacy.

Lotz L, Dittrich R, Hoffmann I, Beckmann M Clin Med Insights Reprod Health. 2019; 13:1179558119867357.

PMID: 31431803 PMC: 6685107. DOI: 10.1177/1179558119867357.