Correlation Between Arterial Blood Volume Obtained by Arterial Spin Labelling and Cerebral Blood Volume in Intracranial Tumours

Overview

Journal MAGMA

Publisher Springer

Date 2011 May 20

PMID 21594585

Citations 19

Authors

Danielle van Westen

Esben T Petersen

Ronnie Wirestam

Roger Siemund

Karin Markenroth Bloch

Freddy Stahlberg

Isabella M Bjorkman-Burtscher

Linda Knutsson

Affiliations

Soon will be listed here.

Abstract

Objective: To compare measurements of the arterial blood volume (aBV), a perfusion parameter calculated from arterial spin labelling (ASL), and cerebral blood volume (CBV), calculated from dynamic susceptibility contrast (DSC) MRI. In the clinic, CBV is used for grading of intracranial tumours.

Materials And Methods: Estimates of aBV from the model-free ASL technique quantitative STAR labelling of arterial regions (QUASAR) experiment and of DSC-CBV were obtained at 3T in ten patients with eleven tumours (three grade III gliomas, four glioblastomas and four meningiomas, two in one patient). Parametric values of aBV and CBV were determined in the tumour as well as in normal grey matter (GM), and tumour-to-GM aBV and CBV ratios were calculated.

Results: In a 4-pixel ROI representing maximal tumour values, the coefficient of determination R (2) was 0.61 for the comparison of ASL-based aBV tumour-to-GM ratios and DSC-MRI-based CBV tumour-to-GM ratios and 0.29 for the comparison of parametric values of ASL-aBV and DSC-CBV, under the assumption of proportionality. Both aBV and CBV showed a non-significant tendency to increase when going from grade III gliomas to glioblastomas to meningiomas.

Conclusion: These results suggest that measurement of aBV is a potential tool for non-invasive assessment of blood volume in intracranial tumours.

Citing Articles

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