Bookmarking the Genome: Maintenance of Epigenetic Information

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2011 Apr 2

PMID 21454629

Citations 42

Authors

Sayyed K Zaidi

Daniel W Young

Martin Montecino

Andre J van Wijnen

Janet L Stein

Jane B Lian

Gary S Stein

Affiliations

Soon will be listed here.

Abstract

Mitotic inheritance of gene function is obligatory to sustain biological control. Emerging evidence suggests that epigenetic mechanisms are linked to transmission of cell fate, lineage commitment, and maintenance of cellular phenotype in progeny cells. Mechanisms of epigenetic memory include gene silencing by DNA methylation, transcriptional regulation by histone modifications, regulation of gene expression by noncoding small RNA molecules, and retention of regulatory machinery on target gene loci for activation and repression. We will focus on the regulatory implications of epigenetic memory for physiological control and for the onset and progression of disease.

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