Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Cell and Tissue Structure, Function, and Phenotype

Overview

Journal Results Probl Cell Differ

Specialty Cell Biology

Date 2022 Nov 8

PMID 36348114

Authors

Andrew J Fritz

Mohammed El Dika

Rabail H Toor

Princess D Rodriguez

Stephen J Foley

Rahim Ullah

Daijing Nie

Bodhisattwa Banerjee

Dorcas Lohese

Kirsten M Tracy

Karen C Glass

Seth Frietze

Prachi N Ghule

Jessica L Heath

Anthony N Imbalzano

Andre Van Wijnen

Jonathan Gordon

Jane B Lian

Janet L Stein

Gary S Stein

Affiliations

Soon will be listed here.

Abstract

Epigenetic gene regulatory mechanisms play a central role in the biological control of cell and tissue structure, function, and phenotype. Identification of epigenetic dysregulation in cancer provides mechanistic into tumor initiation and progression and may prove valuable for a variety of clinical applications. We present an overview of epigenetically driven mechanisms that are obligatory for physiological regulation and parameters of epigenetic control that are modified in tumor cells. The interrelationship between nuclear structure and function is not mutually exclusive but synergistic. We explore concepts influencing the maintenance of chromatin structures, including phase separation, recognition signals, factors that mediate enhancer-promoter looping, and insulation and how these are altered during the cell cycle and in cancer. Understanding how these processes are altered in cancer provides a potential for advancing capabilities for the diagnosis and identification of novel therapeutic targets.

Citing Articles

The emerging role of SARS-CoV-2 nonstructural protein 1 (nsp1) in epigenetic regulation of host gene expression.

Ivanov K, Yang H, Sun R, Li C, Guo D FEMS Microbiol Rev. 2024; 48(5).

PMID: 39231808 PMC: 11418652. DOI: 10.1093/femsre/fuae023.

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