Large-scale Asymmetric Synthesis of the Bioprotective Agent JP4-039 and Analogs

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2011 Apr 2

PMID 21452836

Citations 21

Authors

Marie-Celine Frantz

Joshua G Pierce

Joan M Pierce

Li Kangying

Wan Qingwei

Matthew Johnson

Peter Wipf

Affiliations

Soon will be listed here.

Abstract

JP4-039 is a novel nitroxide conjugate capable of crossing lipid bilayer membranes and scavenging reactive oxygen species (ROS). An efficient and scalable one-pot hydrozirconation-transmetalation-imine addition methodology has been developed for its asymmetric preparation. Furthermore, this versatile methodology allows for the synthesis of cyclopropyl and fluorinated analogs of the parent lead structure.

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