Selective Expression of CD8 Alpha (Ly-2) Subunit on Activated Thymic Gamma/delta Cells

Overview

Journal Eur J Immunol

Specialty Allergy & Immunology

Date 1990 Apr 1

PMID 2140790

Citations 15

Authors

H R MacDonald

M Schreyer

R C Howe

C Bron

Affiliations

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Abstract

Although most cells of the T cell receptor (TcR) gamma/delta lineage are CD4-CD8-, some gamma/delta cells express CD8. We show here that mouse thymic gamma/delta cells express CD8 following in vitro activation by concanavalin A. Staining with monoclonal and polyclonal antibodies to the CD8 alpha (Ly-2) and CD8 beta (Ly-3) subunits indicates that only CD8 alpha is expressed by these activated TcR gamma/delta cells. Furthermore, immunoprecipitation and reduced/nonreduced gel analysis reveals that thymic gamma/delta cells express CD8 alpha as a homodimer. In contrast, similarly activated TcR alpha/beta cells express a conventional CD8 alpha/CD8 beta heterodimer.

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