CD8+ T Cells Respond Clonally to Mls-1a-encoded Determinants

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1990 Apr 1

PMID 2139105

Citations 11

Authors

H R MacDonald

R K Lees

Y Chvatchko

Affiliations

Soon will be listed here.

Abstract

T cell responses to the product of the minor lymphocyte stimulatory locus Mls-1a involve the selective use of TCR V beta domains (especially V beta 6 and V beta 8.1) and are generally considered to be restricted to the CD4+ mature subset. We show here that CD8+ (presumably MHC class I-restricted) T cells bearing V beta 6 or V beta 8.1 also respond preferentially to Mls-1a determinants either in vitro (in mixed leukocyte cultures) or in vivo (in an adoptive transfer system). In vitro responses of both CD4+ V beta 6+ and CD8+ V beta 6+ cells to Mls-1a were dependent upon the MHC haplotype of the stimulator cells, with I-E+ (H-2d or H-2k) alleles being much more stimulatory than I-E- (H-2q). These data strengthen the analogy between Mls gene products and other MHC class II-dependent superantigens such as the bacterial enterotoxins.

Citing Articles

Intestinal Immune System and Amplification of Mouse Mammary Tumor Virus.

Chen L, Zhang X, Liu G, Chen S, Zheng M, Zhu S Front Cell Infect Microbiol. 2022; 11:807462.

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Pathogenesis of an infectious mononucleosis-like disease induced by a murine gamma-herpesvirus: role for a viral superantigen?.

Tripp R, Cardin R, Nguyen P, Behm F, Woodland D, Doherty P J Exp Med. 1997; 185(9):1641-50.

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Role of the T cell receptor alpha-chain in superantigen recognition.

Blackman M, Woodland D Immunol Res. 1996; 15(2):98-113.

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Concomitant enhancement of the response to Mls-1a antigens and the induction of post-thymectomy autoimmune gastritis in BALB/c mice.

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Direct evidence for clonal destruction of allo-reactive T cells in the mice treated with cyclophosphamide after allo-priming.

Maeda T, Eto M, Nishimura Y, Kong Y, Nomoto K Immunology. 1993; 78(1):113-21.

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References

Festenstein H . Immunogenetic and biological aspects of in vitro lymphocyte allotransformation (MLR) in the mouse. Transplant Rev. 1973; 15:62-88. DOI: 10.1111/j.1600-065x.1973.tb00111.x. View

Kurnick J, Gronvik K, Kimura A, Lindblom J, Skoog V, Sjoberg O . Long term growth in vitro of human T cell blasts with maintenance of specificity and function. J Immunol. 1979; 122(4):1255-60. View

Braciale V, Braciale T . MIs locus recognition by a cloned line of H-2-restricted influenza virus-specific cytotoxic T lymphocytes. J Immunol. 1981; 127(3):859-62. View

Festenstein H, Berumen L . BALB.D2-Mlsa--a new congenic mouse strain. Transplantation. 1984; 37(3):322-4. DOI: 10.1097/00007890-198403000-00024. View

DeKruyff R, Ju S, Laning J, CANTOR H, Dorf M . Activation requirements of cloned inducer T cells. III. Need for two stimulator cells in the response of a cloned line to Mls determinants. J Immunol. 1986; 137(4):1109-14. View

White J, Herman A, Pullen A, Kubo R, Kappler J, Marrack P . The V beta-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell. 1989; 56(1):27-35. DOI: 10.1016/0092-8674(89)90980-x. View

Gao E, Kanagawa O, Sprent J . Capacity of unprimed CD4+ and CD8+ T cells expressing V beta 11 receptors to respond to I-E alloantigens in vivo. J Exp Med. 1989; 170(6):1947-57. PMC: 2189546. DOI: 10.1084/jem.170.6.1947. View

Fowlkes B, Pardoll D . Molecular and cellular events of T cell development. Adv Immunol. 1989; 44:207-64. DOI: 10.1016/s0065-2776(08)60643-4. View

Abe R, Hodes R . T-cell recognition of minor lymphocyte stimulating (Mls) gene products. Annu Rev Immunol. 1989; 7:683-708. DOI: 10.1146/annurev.iy.07.040189.003343. View

10.

Happ M, Woodland D, Palmer E . A third T-cell receptor beta-chain variable region gene encodes reactivity to Mls-1a gene products. Proc Natl Acad Sci U S A. 1989; 86(16):6293-6. PMC: 297824. DOI: 10.1073/pnas.86.16.6293. View

11.

Kanagawa O, Maki R . Inhibition of MHC class II-restricted T cell response by Lyt-2 alloantigen. J Exp Med. 1989; 170(3):901-12. PMC: 2189444. DOI: 10.1084/jem.170.3.901. View

12.

Fleischer B . Bacterial toxins as probes for the T-cell antigen receptor. Immunol Today. 1989; 10(8):262-4. DOI: 10.1016/0167-5699(89)90137-0. View

13.

Burgert H, White J, Weltzien H, Marrack P, Kappler J . Reactivity of V beta 17a+ CD8+ T cell hybrids. Analysis using a new CD8+ T cell fusion partner. J Exp Med. 1989; 170(6):1887-904. PMC: 2189549. DOI: 10.1084/jem.170.6.1887. View

14.

Janeway Jr C, Yagi J, Conrad P, Katz M, Jones B, Vroegop S . T-cell responses to Mls and to bacterial proteins that mimic its behavior. Immunol Rev. 1989; 107:61-88. DOI: 10.1111/j.1600-065x.1989.tb00003.x. View