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Telomere Length in Vascular Tissues from Patients with Atherosclerotic Disease

Overview

Overview

Journal J Nutr Health Aging

Specialties Geriatrics
Nutritional Sciences

Date 2011 Mar 3

PMID 21365170

Citations 20

Authors

Authors

R Nzietchueng

M Elfarra

J Nloga

C Labat

J P Carteaux

P Maureira

P Lacolley

J P Villemot

A Benetos

Affiliations

Affiliations

Soon will be listed here.

Abstract

Objectives: The present study was aimed at evaluating telomere length in blood and in different vascular tissues with or without atheroma, in 3 groups of subjects: a group of atherosclerotic subjects who underwent surgery (Atherosclerosis-Surgery), a second group of subjects with asymptomatic atherosclerotic carotid plaques but who did not undergo cardiovascular surgery (Atherosclerosis-No surgery), and a third group of subjects without atherosclerotic disease (Controls). The main objective was to determine if there is in vivo regulation of telomere length in situ by atherosclerotic lesions.

Methods: A total of 84 subjects (mean age 69 ± 8 years) were studied. Blood and arterial tissue telomere lengths were determined by Southern blotting. Personal medical history (diabetes, hypertension, cardiovascular disease, dyslipidemia), family medical history, drug intake, and lifestyle were evaluated in the entire population through the use of a questionnaire.

Results And Conclusion: Arterial segments which did not develop atherosclerosis such as the saphenous vein and internal mammary artery, had longer telomere length than aortic segments. On the other hand, telomere length was shorter in aortic tissues which presented atherosclerotic lesions compared to corresponding tissues without atherosclerotic lesions. These results also suggest tissue regulation of telomere size by local factors likely related to oxidative stress responses.

Citing Articles

Telomere Length: A Cardiovascular Biomarker and a Novel Therapeutic Target.

Sagris M, Theofilis P, Antonopoulos A, Tsioufis K, Tousoulis D Int J Mol Sci. 2022; 23(24).

PMID: 36555658 PMC: 9781338. DOI: 10.3390/ijms232416010.

Theories and Molecular Basis of Vascular Aging: A Review of the Literature from VascAgeNet Group on Pathophysiological Mechanisms of Vascular Aging.

Gkaliagkousi E, Lazaridis A, Dogan S, Fraenkel E, Guvenc Tuna B, Mozos I Int J Mol Sci. 2022; 23(15).

PMID: 35955804 PMC: 9368987. DOI: 10.3390/ijms23158672.

The Length of Leukocyte and Femoral Artery Telomeres in Patients with Peripheral Atherosclerosis.

Boniewska-Bernacka E, Panczyszyn A, Hobot J, Donizy P, Ziembik Z, Goc A Genes (Basel). 2022; 13(4).

PMID: 35456510 PMC: 9030852. DOI: 10.3390/genes13040704.

Telomere Length in Valve Tissue Is Shorter in Individuals With Aortic Stenosis and in Calcified Valve Areas.

Saraieva I, Benetos A, Labat C, Franco-Cereceda A, Back M, Toupance S Front Cell Dev Biol. 2021; 9:618335.

PMID: 33777932 PMC: 7990782. DOI: 10.3389/fcell.2021.618335.

Role of Telomeres Shortening in Atherogenesis: An Overview.

Yegorov Y, Poznyak A, Nikiforov N, Starodubova A, Orekhov A Cells. 2021; 10(2).

PMID: 33671887 PMC: 7918954. DOI: 10.3390/cells10020395.

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