The Use of Endophytes to Obtain Bioactive Compounds and Their Application in Biotransformation Process

Overview

Journal Biotechnol Res Int

Publisher Hindawi

Specialty Biotechnology

Date 2011 Feb 26

PMID 21350663

Citations 46

Authors

Mariana Recco Pimentel

Gustavo Molina

Ana Paula Dionisio

Mario Roberto Marostica Junior

Glaucia Maria Pastore

Affiliations

Soon will be listed here.

Abstract

Endophytes are microorganisms that reside asymptomatically in the tissues of higher plants and are a promising source of novel organic natural metabolites exhibiting a variety of biological activities. The laboratory of Bioaromas (Unicamp, Brazil) develops research in biotransformation processes and functional evaluation of natural products. With the intent to provide subsidies for studies on endophytic microbes related to areas cited before, this paper focuses particularly on the role of endophytes on the production of anticancer, antimicrobial, and antioxidant compounds and includes examples that illustrate their potential for human use. It also describes biotransformation as an auspicious method to obtain novel bioactive compounds from microbes. Biotransformation allows the production of regio- and stereoselective compounds under mild conditions that can be labeled as "natural," as discussed in this paper.

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