The Ups and Downs of Tannins As Inhibitors of Poly(ADP-ribose)glycohydrolase

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2011 Feb 24

PMID 21343889

Citations 13

Authors

Christian Blenn

Philippe Wyrsch

Felix R Althaus

Affiliations

Soon will be listed here.

Abstract

DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action. Naturally appearing tannin-like molecules have been implicated in specific inhibition of the PARG enzyme. This review deals with the in vitro and in vivo effects of tannins on PAR metabolism and their downstream actions in DNA damage signaling.

Citing Articles

Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.

Houl J, Ye Z, Brosey C, Balapiti-Modarage L, Namjoshi S, Bacolla A Nat Commun. 2019; 10(1):5654.

PMID: 31827085 PMC: 6906431. DOI: 10.1038/s41467-019-13508-4.

Comprehensive analysis of telomerase inhibition by gallotannin.

Savelyev N, Baykuzina P, Dokudovskaya S, Lavrik O, Rubtsova M, Dontsova O Oncotarget. 2018; 9(27):18712-18719.

PMID: 29721155 PMC: 5922349. DOI: 10.18632/oncotarget.24642.

PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency.

Noll A, Illuzzi G, Ame J, Dantzer F, Schreiber V Cancer Cell Int. 2016; 16:53.

PMID: 27375368 PMC: 4929728. DOI: 10.1186/s12935-016-0333-2.

The rise and fall of poly(ADP-ribose): An enzymatic perspective.

Pascal J, Ellenberger T DNA Repair (Amst). 2015; 32:10-16.

PMID: 25963443 PMC: 4522361. DOI: 10.1016/j.dnarep.2015.04.008.

Corilagin attenuates aerosol bleomycin-induced experimental lung injury.

Wang Z, Guo Q, Zhang X, Li X, Li W, Ma X Int J Mol Sci. 2014; 15(6):9762-79.

PMID: 24886817 PMC: 4100119. DOI: 10.3390/ijms15069762.

References

Haince J, McDonald D, Rodrigue A, Dery U, Masson J, Hendzel M . PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. J Biol Chem. 2007; 283(2):1197-208. DOI: 10.1074/jbc.M706734200. View

Gao H, Coyle D, Meyer-Ficca M, Meyer R, Jacobson E, Wang Z . Altered poly(ADP-ribose) metabolism impairs cellular responses to genotoxic stress in a hypomorphic mutant of poly(ADP-ribose) glycohydrolase. Exp Cell Res. 2007; 313(5):984-96. DOI: 10.1016/j.yexcr.2006.12.025. View

Meyer-Ficca M, Meyer R, Coyle D, Jacobson E, Jacobson M . Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments. Exp Cell Res. 2004; 297(2):521-32. DOI: 10.1016/j.yexcr.2004.03.050. View

Whatcott C, Meyer-Ficca M, Meyer R, Jacobson M . A specific isoform of poly(ADP-ribose) glycohydrolase is targeted to the mitochondrial matrix by a N-terminal mitochondrial targeting sequence. Exp Cell Res. 2009; 315(20):3477-85. PMC: 2787692. DOI: 10.1016/j.yexcr.2009.04.005. View

Artus C, Boujrad H, Bouharrour A, Brunelle M, Hoos S, Yuste V . AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX. EMBO J. 2010; 29(9):1585-99. PMC: 2876946. DOI: 10.1038/emboj.2010.43. View

Tikoo K, Bhatt D, Gaikwad A, Sharma V, Kabra D . Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats. FEBS Lett. 2007; 581(10):2027-35. DOI: 10.1016/j.febslet.2007.04.036. View

Ying W, Sevigny M, Chen Y, Swanson R . Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death. Proc Natl Acad Sci U S A. 2001; 98(21):12227-32. PMC: 59796. DOI: 10.1073/pnas.211202598. View

DAmours D, Desnoyers S, DSilva I, Poirier G . Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J. 1999; 342 ( Pt 2):249-68. PMC: 1220459. View

Brochu G, Duchaine C, Thibeault L, Lagueux J, Shah G, Poirier G . Mode of action of poly(ADP-ribose) glycohydrolase. Biochim Biophys Acta. 1994; 1219(2):342-50. DOI: 10.1016/0167-4781(94)90058-2. View

10.

Tikoo K, Tamta A, Ali I, Gupta J, Gaikwad A . Tannic acid prevents azidothymidine (AZT) induced hepatotoxicity and genotoxicity along with change in expression of PARG and histone H3 acetylation. Toxicol Lett. 2008; 177(2):90-6. DOI: 10.1016/j.toxlet.2007.12.012. View

11.

Tsai Y, Abe H, Maruta H, Hatano T, Nishina H, Sakagami H . Effects of chemically defined tannins on poly (ADP-ribose) glycohydrolase activity. Biochem Int. 1991; 24(5):889-97. View

12.

Haince J, Kozlov S, Dawson V, Dawson T, Hendzel M, Lavin M . Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents. J Biol Chem. 2007; 282(22):16441-53. DOI: 10.1074/jbc.M608406200. View

13.

Zhou Y, Feng X, Koh D . Enhanced DNA accessibility and increased DNA damage induced by the absence of poly(ADP-ribose) hydrolysis. Biochemistry. 2010; 49(34):7360-6. DOI: 10.1021/bi100979j. View

14.

Schreiber V, Dantzer F, Ame J, de Murcia G . Poly(ADP-ribose): novel functions for an old molecule. Nat Rev Mol Cell Biol. 2006; 7(7):517-28. DOI: 10.1038/nrm1963. View

15.

Mullen W, McGinn J, Lean M, MacLean M, Gardner P, Duthie G . Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties. J Agric Food Chem. 2002; 50(18):5191-6. DOI: 10.1021/jf020140n. View

16.

Erdelyi K, Kiss A, Bakondi E, Bai P, Szabo C, Gergely P . Gallotannin inhibits the expression of chemokines and inflammatory cytokines in A549 cells. Mol Pharmacol. 2005; 68(3):895-904. DOI: 10.1124/mol.105.012518. View

17.

Serrano J, Puupponen-Pimia R, Dauer A, Aura A, Saura-Calixto F . Tannins: current knowledge of food sources, intake, bioavailability and biological effects. Mol Nutr Food Res. 2009; 53 Suppl 2:S310-29. DOI: 10.1002/mnfr.200900039. View

18.

Lu X, Massuda E, Lin Q, Li W, Li J, Zhang J . Post-treatment with a novel PARG inhibitor reduces infarct in cerebral ischemia in the rat. Brain Res. 2003; 978(1-2):99-103. DOI: 10.1016/s0006-8993(03)02774-4. View

19.

Okita N, Ashizawa D, Ohta R, Abe H, Tanuma S . Discovery of novel poly(ADP-ribose) glycohydrolase inhibitors by a quantitative assay system using dot-blot with anti-poly(ADP-ribose). Biochem Biophys Res Commun. 2010; 392(4):485-9. DOI: 10.1016/j.bbrc.2010.01.044. View

20.

Keil C, Petermann E, Oei S . Tannins elevate the level of poly(ADP-ribose) in HeLa cell extracts. Arch Biochem Biophys. 2004; 425(1):115-21. DOI: 10.1016/j.abb.2004.02.024. View