Philippe Wyrsch
Overview
Explore the profile of Philippe Wyrsch including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
106
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0
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Recent Articles
1.
Pesch T, Schuhwerk H, Wyrsch P, Immel T, Dirks W, Burkle A, et al.
BMC Cancer
. 2016 Jul;
16:469.
PMID: 27412346
Background: Chemotherapy is one of the major treatment modalities for cancer. Metal-based compounds such as derivatives of cisplatin are in the front line of therapy against a subset of cancers,...
2.
Blenn C, Wyrsch P, Althaus F
Genes (Basel)
. 2014 Apr;
3(4):779-805.
PMID: 24705085
Poly(ADP-ribosyl)-ation is a nonprotein posttranslational modification of proteins and plays an integral part in cell physiology and pathology. The metabolism of poly(ADP-ribose) (PAR) is regulated by its synthesis by poly(ADP-ribose)...
3.
Wyrsch P, Blenn C, Pesch T, Beneke S, Althaus F
Cell Commun Signal
. 2013 Feb;
11(1):11.
PMID: 23384168
The determination of the cytotoxic potential of new and so far unknown compounds as well as their metabolites is fundamental in risk assessment. A variety of strategic endpoints have been...
4.
Wyrsch P, Blenn C, Bader J, Althaus F
Mol Cell Biol
. 2012 Jul;
32(17):3541-53.
PMID: 22751932
On the cellular level, oxidative stress may cause various responses, including autophagy and cell death. All of these outcomes involve disturbed Ca(2+) signaling. Here we show that the nuclear enzymes...
5.
Blenn C, Wyrsch P, Althaus F
Molecules
. 2011 Feb;
16(2):1854-77.
PMID: 21343889
DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action. Naturally appearing tannin-like molecules have been...
6.
Walton S, Wyrsch P, Munks M, Zimmermann A, Hengel H, Hill A, et al.
J Immunol
. 2008 Jul;
181(2):1128-34.
PMID: 18606665
The dynamics of mouse cytomegalovirus (MCMV)-specific CD4 T cell responses and the mechanisms by which these cells contribute to viral control are not well understood, mainly due to lack of...