Tannins, Peptic Ulcers and Related Mechanisms

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2012 Apr 11

PMID 22489149

Citations 40

Authors

Neyres Zinia Taveira de Jesus

Heloina de Souza Falcao

Isis Fernandes Gomes

Thiago Jose de Almeida Leite

Gedson Rodrigues de Morais Lima

Jose Maria Barbosa-Filho

Josean Fechine Tavares

Marcelo Sobral da Silva

Petronio Filgueiras de Athayde-Filho

Leonia Maria Batista

Affiliations

Soon will be listed here.

Abstract

This review of the current literature aims to study correlations between the chemical structure and gastric anti-ulcer activity of tannins. Tannins are used in medicine primarily because of their astringent properties. These properties are due to the fact that tannins react with the tissue proteins with which they come into contact. In gastric ulcers, this tannin-protein complex layer protects the stomach by promoting greater resistance to chemical and mechanical injury or irritation. Moreover, in several experimental models of gastric ulcer, tannins have been shown to present antioxidant activity, promote tissue repair, exhibit anti Helicobacter pylori effects, and they are involved in gastrointestinal tract anti-inflammatory processes. The presence of tannins explains the anti-ulcer effects of many natural products.

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