Nanoparticle-functionalized Porous Polymer Monolith Detection Elements for Surface-enhanced Raman Scattering

Overview

Journal Anal Chem

Specialty Chemistry

Date 2011 Feb 17

PMID 21322579

Citations 9

Authors

Jikun Liu

Ian White

Don L DeVoe

Affiliations

Soon will be listed here.

Abstract

The use of porous polymer monoliths functionalized with silver nanoparticles is introduced in this work for high-sensitivity surface-enhanced Raman scattering (SERS) detection. Preparation of the SERS detection elements is a simple process comprising the synthesis of a discrete polymer monolith section within a silica capillary, followed by physically trapping silver nanoparticle aggregates within the monolith matrix. A SERS detection limit of 220 fmol for Rhodamine 6G is demonstrated, with excellent signal stability over a 24 h period. The capability of the SERS-active monolith for label-free detection of biomolecules was demonstrated by measurements of bradykinin and cytochrome c. The SERS-active monoliths can be readily integrated into miniaturized micrototal-analysis systems for online and label-free detection for a variety of biosensing, bioanalytical, and biomedical applications.

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References

Svec F, Huber C . Monolithic materials: Promises, challenges, achievements. Anal Chem. 2006; 78(7):2101-7. DOI: 10.1021/ac069383v. View

Svec F . Porous polymer monoliths: amazingly wide variety of techniques enabling their preparation. J Chromatogr A. 2009; 1217(6):902-24. PMC: 2829304. DOI: 10.1016/j.chroma.2009.09.073. View

Kennedy D, Hoop K, Tay L, Pezacki J . Development of nanoparticle probes for multiplex SERS imaging of cell surface proteins. Nanoscale. 2010; 2(8):1413-6. DOI: 10.1039/c0nr00122h. View

Hering K, Cialla D, Ackermann K, Dorfer T, Moller R, Schneidewind H . SERS: a versatile tool in chemical and biochemical diagnostics. Anal Bioanal Chem. 2007; 390(1):113-24. DOI: 10.1007/s00216-007-1667-3. View

Li Y, Gu B, Tolley H, Lee M . Preparation of polymeric monoliths by copolymerization of acrylate monomers with amine functionalities for anion-exchange capillary liquid chromatography of proteins. J Chromatogr A. 2009; 1216(29):5525-32. DOI: 10.1016/j.chroma.2009.05.037. View

Sundararajan N, Mao D, Chan S, Koo T, Su X, Sun L . Ultrasensitive detection and characterization of posttranslational modifications using surface-enhanced Raman spectroscopy. Anal Chem. 2006; 78(11):3543-50. DOI: 10.1021/ac051525i. View

Camden J, Dieringer J, Wang Y, Masiello D, Marks L, Schatz G . Probing the structure of single-molecule surface-enhanced Raman scattering hot spots. J Am Chem Soc. 2008; 130(38):12616-7. DOI: 10.1021/ja8051427. View

Kahraman M, Sur I, Culha M . Label-free detection of proteins from self-assembled protein-silver nanoparticle structures using surface-enhanced Raman scattering. Anal Chem. 2010; 82(18):7596-602. DOI: 10.1021/ac101720s. View

Kneipp J, Kneipp H, McLaughlin M, Brown D, Kneipp K . In vivo molecular probing of cellular compartments with gold nanoparticles and nanoaggregates. Nano Lett. 2006; 6(10):2225-31. DOI: 10.1021/nl061517x. View

10.

Guiochon G . Monolithic columns in high-performance liquid chromatography. J Chromatogr A. 2007; 1168(1-2):101-68. DOI: 10.1016/j.chroma.2007.05.090. View

11.

Golightly R, Doering W, Natan M . Surface-enhanced Raman spectroscopy and homeland security: a perfect match?. ACS Nano. 2009; 3(10):2859-69. DOI: 10.1021/nn9013593. View

12.

Kneipp J, Kneipp H, Kneipp K . SERS--a single-molecule and nanoscale tool for bioanalytics. Chem Soc Rev. 2008; 37(5):1052-60. DOI: 10.1039/b708459p. View

13.

Fox J, Vavrek R, Tu A, Stewart J . Raman studies on bradykinin and a cyclic bradykinin. Peptides. 1982; 3(2):193-8. DOI: 10.1016/0196-9781(82)90050-x. View

14.

Koerner T, Turck K, Brown L, Oleschuk R . Porous polymer monolith assisted electrospray. Anal Chem. 2004; 76(21):6456-60. DOI: 10.1021/ac049438y. View

15.

Xu Y, Cao Q, Svec F, Frechet J . Porous polymer monolithic column with surface-bound gold nanoparticles for the capture and separation of cysteine-containing peptides. Anal Chem. 2010; 82(8):3352-8. PMC: 2875083. DOI: 10.1021/ac1002646. View

16.

Nie , Emory . Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering. Science. 1997; 275(5303):1102-6. DOI: 10.1126/science.275.5303.1102. View

17.

Liu X, Kim C, Yang J, Jemmerson R, Wang X . Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell. 1996; 86(1):147-57. DOI: 10.1016/s0092-8674(00)80085-9. View

18.

Regoli D, Barabe J . Pharmacology of bradykinin and related kinins. Pharmacol Rev. 1980; 32(1):1-46. View

19.

Han X, Huang G, Zhao B, Ozaki Y . Label-free highly sensitive detection of proteins in aqueous solutions using surface-enhanced Raman scattering. Anal Chem. 2009; 81(9):3329-33. DOI: 10.1021/ac900395x. View

20.

Svec F . Preparation and HPLC applications of rigid macroporous organic polymer monoliths. J Sep Sci. 2004; 27(10-11):747-66. DOI: 10.1002/jssc.200401721. View