SERS--a Single-molecule and Nanoscale Tool for Bioanalytics

Overview

Journal Chem Soc Rev

Specialty Chemistry

Date 2008 Apr 30

PMID 18443689

Citations 148

Authors

Janina Kneipp

Harald Kneipp

Katrin Kneipp

Affiliations

Soon will be listed here.

Abstract

Surface enhanced Raman scattering (SERS) at extremely high enhancement level turns the weak inelastic scattering effect of photons on vibrational quantum states into a structurally sensitive single-molecule and nanoscale probe. The effect opens up exciting opportunities for applications of vibrational spectroscopy in biology. The concept of SERS can be extended to two-photon excitation by exploiting surface enhanced hyper-Raman scattering (SEHRS). This critical review introduces the physics behind single-molecule SERS and discusses the capabilities of the effect in bioanalytics (100 references).

Citing Articles

Metal-organic framework-based SERS probes with enrichment capability for trace detection: applications in biomarkers and pollutants.

Quan Y, Weng G, Zhu J, Li J, Zhao J Mikrochim Acta. 2025; 192(3):200.

PMID: 40029454 DOI: 10.1007/s00604-025-07055-7.

Label-Free Surface-Enhanced Raman Scattering for Genomic DNA Cytosine Methylation Reading.

Alom K, Tukova A, Lyu N, Rodger A, Wang Y Molecules. 2025; 30(2).

PMID: 39860272 PMC: 11767753. DOI: 10.3390/molecules30020403.

Ultra-Sensitive Detection of Bacterial Spores via SERS.

Segervald J, Malyshev D, Oberg R, Zall E, Jia X, Wagberg T ACS Sens. 2025; 10(2):1237-1248.

PMID: 39847439 PMC: 11877637. DOI: 10.1021/acssensors.4c03151.

Gold Nanoprism Enhanced SERS Aptasensor for Simultaneous Detection of Thrombin and VEGF.

Anantha P, Raj P, Zheng P, Tanwar S, Barman I Sens Actuators B Chem. 2025; 423.

PMID: 39744119 PMC: 11687365. DOI: 10.1016/j.snb.2024.136811.

Strongly coupled Raman scattering enhancement revealed by scattering-type scanning near-field optical microscopy.

Qin K, Liu K, Peng S, Zuo Z, He X, Ding J Nanophotonics. 2024; 12(10):1857-1864.

PMID: 39635140 PMC: 11502024. DOI: 10.1515/nanoph-2023-0016.