Methacrylate Polymer Monoliths for Separation Applications

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2017 Aug 5

PMID 28773570

Citations 6

Authors

Robert J Groarke

Dermot Brabazon

Affiliations

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Abstract

This review summarizes the development of methacrylate-based polymer monoliths for separation science applications. An introduction to monoliths is presented, followed by the preparation methods and characteristics specific to methacrylate monoliths. Both traditional chemical based syntheses and emerging additive manufacturing methods are presented along with an analysis of the different types of functional groups, which have been utilized with methacrylate monoliths. The role of methacrylate based porous materials in separation science in industrially important chemical and biological separations are discussed, with particular attention given to the most recent developments and challenges associated with these materials. While these monoliths have been shown to be useful for a wide variety of applications, there is still scope for exerting better control over the porous architectures and chemistries obtained from the different fabrication routes. Conclusions regarding this previous work are drawn and an outlook towards future challenges and potential developments in this vibrant research area are presented. Discussed in particular are the potential of additive manufacturing for the preparation of monolithic structures with pre-defined multi-scale porous morphologies and for the optimization of surface reactive chemistries.

Citing Articles

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References

Smrekar F, Ciringer M, Strancar A, Podgornik A . Characterisation of methacrylate monoliths for bacteriophage purification. J Chromatogr A. 2011; 1218(17):2438-44. DOI: 10.1016/j.chroma.2010.12.083. View

Laher M, Causon T, Buchberger W, Hild S, Nischang I . Assessing the nanoscale structure and mechanical properties of polymer monoliths used for chromatography. Anal Chem. 2013; 85(12):5645-9. DOI: 10.1021/ac401303k. View

Zhao Q, Li X, Le X . Aptamer-modified monolithic capillary chromatography for protein separation and detection. Anal Chem. 2008; 80(10):3915-20. DOI: 10.1021/ac702567x. View

Guo J, Zhang Q, Yao Z, Zhao X, Ran D, Crommen J . One-step strategy for the synthesis of a derivatized cyclodextrin-based monolithic column. J Sep Sci. 2014; 37(14):1720-7. DOI: 10.1002/jssc.201400312. View

Guo J, Zhang Q, Peng Y, Liu Z, Rao L, He T . A facile and efficient one-step strategy for the preparation of β-cyclodextrin monoliths. J Sep Sci. 2013; 36(15):2441-9. DOI: 10.1002/jssc.201300374. View

Jiang Z, Smith N, Ferguson P, Taylor M . Mixed-mode reversed-phase and ion-exchange monolithic columns for micro-HPLC. J Sep Sci. 2008; 31(15):2774-83. DOI: 10.1002/jssc.200800124. View

Arrua R, Hitchcock A, Hon W, West M, Hilder E . Characterization of polymer monoliths containing embedded nanoparticles by scanning transmission X-ray microscopy (STXM). Anal Chem. 2014; 86(6):2876-81. DOI: 10.1021/ac403166u. View

Kolb H, Finn M, Sharpless K . Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Angew Chem Int Ed Engl. 2001; 40(11):2004-2021. DOI: 10.1002/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5. View

Nge P, Rogers C, Woolley A . Advances in microfluidic materials, functions, integration, and applications. Chem Rev. 2013; 113(4):2550-83. PMC: 3624029. DOI: 10.1021/cr300337x. View

10.

Kip C, Erkakan D, Gokaltun A, Celebi B, Tuncel A . Synthesis of a reactive polymethacrylate capillary monolith and its use as a starting material for the preparation of a stationary phase for hydrophilic interaction chromatography. J Chromatogr A. 2015; 1396:86-97. DOI: 10.1016/j.chroma.2015.04.005. View

11.

Krajnc P, Leber N, Stefanec D, Kontrec S, Podgornik A . Preparation and characterisation of poly(high internal phase emulsion) methacrylate monoliths and their application as separation media. J Chromatogr A. 2005; 1065(1):69-73. DOI: 10.1016/j.chroma.2004.10.051. View

12.

Jandera P, Urban J, Moravcova D . Polymetacrylate and hybrid interparticle monolithic columns for fast separations of proteins by capillary liquid chromatography. J Chromatogr A. 2005; 1109(1):60-73. DOI: 10.1016/j.chroma.2005.08.085. View

13.

Li M, Tarawally M, Liu X, Liu X, Guo L, Yang L . Application of cyclodextrin-modified gold nanoparticles in enantioselective monolith capillary electrochromatography. Talanta. 2013; 109:1-6. DOI: 10.1016/j.talanta.2013.03.035. View

14.

Sun X, He X, Chen L, Zhang Y . In-column "click" preparation of hydrophobic organic monolithic stationary phases for protein separation. Anal Bioanal Chem. 2010; 399(10):3407-13. DOI: 10.1007/s00216-010-4390-4. View

15.

Zhang H, Ou J, Wei Y, Wang H, Liu Z, Chen L . A novel polymeric monolith prepared with multi-acrylate crosslinker for retention-independent efficient separation of small molecules in capillary liquid chromatography. Anal Chim Acta. 2015; 883:90-8. DOI: 10.1016/j.aca.2015.04.001. View

16.

Walsh Z, Abele S, Lawless B, Heger D, Klan P, Breadmore M . Photoinitiated polymerisation of monolithic stationary phases in polyimide coated capillaries using visible region LEDs. Chem Commun (Camb). 2008; (48):6504-6. DOI: 10.1039/b816958f. View

17.

Chen X, Tolley H, Lee M . Monolithic capillary columns synthesized from a single phosphate-containing dimethacrylate monomer for cation-exchange chromatography of peptides and proteins. J Chromatogr A. 2011; 1218(28):4322-31. DOI: 10.1016/j.chroma.2011.04.074. View

18.

Liu W, Lirio S, Yang Y, Wu L, Hsiao S, Huang H . A poly(alkyl methacrylate-divinylbenzene-vinylbenzyl trimethylammonium chloride) monolithic column for solid-phase microextraction. J Chromatogr A. 2015; 1395:32-40. DOI: 10.1016/j.chroma.2015.03.066. View

19.

Mullner T, Zankel A, Mayrhofer C, Reingruber H, Holtzel A, Lv Y . Reconstruction and characterization of a polymer-based monolithic stationary phase using serial block-face scanning electron microscopy. Langmuir. 2012; 28(49):16733-7. DOI: 10.1021/la3038395. View

20.

Hu Y, Fan Y, Li G . Preparation and evaluation of a porous monolithic capillary column for microextraction of estrogens from urine and milk samples online coupled to high-performance liquid chromatography. J Chromatogr A. 2011; 1228:205-12. DOI: 10.1016/j.chroma.2011.08.057. View