Transcriptional Regulation by GATA1 and GATA2 During Erythropoiesis

Overview

Journal Int J Hematol

Specialty Hematology

Date 2011 Feb 1

PMID 21279818

Citations 20

Authors

Mikiko Suzuki

Ritsuko Shimizu

Masayuki Yamamoto

Affiliations

Soon will be listed here.

Abstract

The transcription factor GATA1 regulates multiple genes in erythroid lineage cells. However, the means by which GATA1 regulates the expression of target genes during erythropoiesis remains to be elucidated. Three mechanisms have been postulated for the regulation of genes by GATA1. First, individual target genes may have multiple discrete thresholds for cellular GATA1. GATA1 has a dynamic expression profile during erythropoiesis, thus the expression of a set of GATA1 target genes may be triggered at a given stage of differentiation by cellular GATA1. Second, the expression of GATA1 target genes may be modified, at least in part, by GATA2 occupying the GATA-binding motifs. GATA2 is expressed earlier in erythropoiesis than GATA1, and prior GATA2 binding may afford GATA1 access to GATA motifs through epigenetic remodeling and thus facilitate target gene expression. Third, other regulatory molecules specific to each target gene may function cooperatively with GATA1. If GATA1 is required for the expression of such cofactors, a regulatory network will be formed and relevant gene expression will be delayed. We propose that the stage-specific regulation of erythroid genes by GATA1 is tightly controlled through a combination of these mechanisms in vivo.

Citing Articles

Effect of ginsenoside Rg1 on hematopoietic stem cells in treating aplastic anemia in mice MAPK pathway.

Wang J, Du M, Zheng Y World J Stem Cells. 2024; 16(5):591-603.

PMID: 38817329 PMC: 11135254. DOI: 10.4252/wjsc.v16.i5.591.

RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation.

Martell D, Merens H, Caulier A, Fiorini C, Ulirsch J, Ietswaart R Dev Cell. 2023; 58(20):2112-2127.e4.

PMID: 37586368 PMC: 10615711. DOI: 10.1016/j.devcel.2023.07.018.

RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation.

Martell D, Merens H, Fiorini C, Caulier A, Ulirsch J, Ietswaart R medRxiv. 2023; .

PMID: 36945604 PMC: 10029049. DOI: 10.1101/2023.03.03.23286760.

Proerythroblast Cells of Diamond-Blackfan Anemia Patients With and Mutations Have Similar Transcriptomic Signature.

Karaosmanoglu B, Kursunel M, Uckan Cetinkaya D, Gumruk F, Esendagli G, Unal S Front Physiol. 2021; 12:679919.

PMID: 34177624 PMC: 8226250. DOI: 10.3389/fphys.2021.679919.

Control of ribosomal protein synthesis by the Microprocessor complex.

Jiang X, Prabhakar A, van der Voorn S, Ghatpande P, Celona B, Venkataramanan S Sci Signal. 2021; 14(671).

PMID: 33622983 PMC: 8012103. DOI: 10.1126/scisignal.abd2639.

References

Evans T, Reitman M, Felsenfeld G . An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes. Proc Natl Acad Sci U S A. 1988; 85(16):5976-80. PMC: 281888. DOI: 10.1073/pnas.85.16.5976. View

Weiss M, Keller G, Orkin S . Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells. Genes Dev. 1994; 8(10):1184-97. DOI: 10.1101/gad.8.10.1184. View

Martin D, Orkin S . Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1. Genes Dev. 1990; 4(11):1886-98. DOI: 10.1101/gad.4.11.1886. View

Akashi K, Traver D, Miyamoto T, Weissman I . A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 2000; 404(6774):193-7. DOI: 10.1038/35004599. View

Tsai F, Orkin S . Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood. 1997; 89(10):3636-43. View

Romeo P, Prandini M, Joulin V, Mignotte V, PRENANT M, Vainchenker W . Megakaryocytic and erythrocytic lineages share specific transcription factors. Nature. 1990; 344(6265):447-9. DOI: 10.1038/344447a0. View

Tsang A, Visvader J, Turner C, Fujiwara Y, Yu C, Weiss M . FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell. 1997; 90(1):109-19. DOI: 10.1016/s0092-8674(00)80318-9. View

Fujiwara T, OGeen H, Keles S, Blahnik K, Linnemann A, Kang Y . Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009; 36(4):667-81. PMC: 2784893. DOI: 10.1016/j.molcel.2009.11.001. View

Pal S, Cantor A, Johnson K, Moran T, Boyer M, Orkin S . Coregulator-dependent facilitation of chromatin occupancy by GATA-1. Proc Natl Acad Sci U S A. 2004; 101(4):980-5. PMC: 327128. DOI: 10.1073/pnas.0307612100. View

10.

Nichols K, Crispino J, Poncz M, White J, Orkin S, Maris J . Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1. Nat Genet. 2000; 24(3):266-70. PMC: 10576470. DOI: 10.1038/73480. View

11.

Takahashi S, Shimizu R, Suwabe N, Kuroha T, Yoh K, Ohta J . GATA factor transgenes under GATA-1 locus control rescue germline GATA-1 mutant deficiencies. Blood. 2000; 96(3):910-6. View

12.

Suzuki N, Ohneda O, Minegishi N, Nishikawa M, Ohta T, Takahashi S . Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow niche. Proc Natl Acad Sci U S A. 2006; 103(7):2202-7. PMC: 1413708. DOI: 10.1073/pnas.0508928103. View

13.

Drissen R, Guyot B, Zhang L, Atzberger A, Sloane-Stanley J, Wood B . Lineage-specific combinatorial action of enhancers regulates mouse erythroid Gata1 expression. Blood. 2010; 115(17):3463-71. PMC: 2918365. DOI: 10.1182/blood-2009-07-232876. View

14.

Crossley M, Tsang A, Bieker J, Orkin S . Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1. J Biol Chem. 1994; 269(22):15440-4. View

15.

Grass J, Boyer M, Pal S, Wu J, Weiss M, Bresnick E . GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc Natl Acad Sci U S A. 2003; 100(15):8811-6. PMC: 166395. DOI: 10.1073/pnas.1432147100. View

16.

Suzuki N, Suwabe N, Ohneda O, Obara N, Imagawa S, Pan X . Identification and characterization of 2 types of erythroid progenitors that express GATA-1 at distinct levels. Blood. 2003; 102(10):3575-83. DOI: 10.1182/blood-2003-04-1154. View

17.

Gutierrez L, Nikolic T, van Dijk T, Hammad H, Vos N, Willart M . Gata1 regulates dendritic-cell development and survival. Blood. 2007; 110(6):1933-41. PMC: 1975828. DOI: 10.1182/blood-2006-09-048322. View

18.

Onodera K, Takahashi S, Nishimura S, Ohta J, Motohashi H, Yomogida K . GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis. Proc Natl Acad Sci U S A. 1997; 94(9):4487-92. PMC: 20749. DOI: 10.1073/pnas.94.9.4487. View

19.

Cheng Y, Wu W, Kumar S, Yu D, Deng W, Tripic T . Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression. Genome Res. 2009; 19(12):2172-84. PMC: 2792182. DOI: 10.1101/gr.098921.109. View

20.

Landry J, Bonadies N, Kinston S, Knezevic K, Wilson N, Oram S . Expression of the leukemia oncogene Lmo2 is controlled by an array of tissue-specific elements dispersed over 100 kb and bound by Tal1/Lmo2, Ets, and Gata factors. Blood. 2009; 113(23):5783-92. DOI: 10.1182/blood-2008-11-187757. View